AutismKB 2.0

Annotation Detail for NRXN2


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Basic Information Top
Gene Symbol:NRXN2 ( FLJ40892,KIAA0921 )
Gene Full Name: neurexin 2
Band: 11q13.1
Quick LinksEntrez ID:9379; OMIM: 600566; Uniprot ID:NRX2A_HUMAN; ENSEMBL ID: ENSG00000110076; HGNC ID: 8009
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
60N-linked (GlcNAc...) (Potential).
338N-linked (GlcNAc...) (Potential).
841N-linked (GlcNAc...) (Potential).
1236N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
60N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
190N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
338N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
841N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1236N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
10O-linkedHMM predict
54O-linkedHMM predict
54O-linkedHMM predict
55Phosphoserine(CK1)HMM predict
56O-linkedHMM predict
56Phosphoserine(IKK)HMM predict
58Phosphoserine(CK1)HMM predict
60N-linkedHMM predict
62Phosphothreonine(PKA)HMM predict
92Phosphothreonine(PKA)HMM predict
114Phosphothreonine(PKC)HMM predict
162Phosphoserine(PKG)HMM predict
190N-linkedHMM predict
272MethylarginineHMM predict
307O-linkedHMM predict
324O-linkedHMM predict
336Phosphoserine(PKB)HMM predict
336Phosphotyrosine(INSR)HMM predict
338Phosphothreonine(PKC)HMM predict
359Phosphoserine(CK1)HMM predict
394O-linkedHMM predict
413SulfotyrosineHMM predict
416O-linkedHMM predict
418SulfotyrosineHMM predict
427O-linkedHMM predict
438Phosphoserine(CK2)HMM predict
441PhosphoserineHMM predict
441Phosphoserine(CDC2)HMM predict
468Phosphotyrosine(Syk)HMM predict
468Phosphotyrosine(EGFR)HMM predict
475O-linkedHMM predict
482Phosphoserine(CDC2)HMM predict
516Phosphoserine(IKK)HMM predict
547Phosphoserine(CDK)HMM predict
567N-linkedHMM predict
588Phosphoserine(IKK)HMM predict
601Phosphoserine(PKG)HMM predict
630Phosphotyrosine(INSR)HMM predict
652Phosphothreonine(CDK)HMM predict
652Phosphothreonine(MAPK)HMM predict
654Phosphoserine(PKC)HMM predict
659AsparagineHMM predict
740Phosphotyrosine(INSR)HMM predict
834Phosphoserine(PKB)HMM predict
841N-linkedHMM predict
872Phosphoserine(PKB)HMM predict
937Phosphotyrosine(INSR)HMM predict
989O-linkedHMM predict
1160Phosphothreonine(PKC)HMM predict
1236N-linkedHMM predict
1353O-linkedHMM predict
1370O-linkedHMM predict
1382Phosphoserine(PKB)HMM predict
1384Phosphothreonine(PKC)HMM predict
1405Phosphoserine(CK1)HMM predict
1440O-linkedHMM predict
1462O-linkedHMM predict
1473O-linkedHMM predict
1484Phosphoserine(CK2)HMM predict
1514Phosphotyrosine(EGFR)HMM predict
1514Phosphotyrosine(Syk)HMM predict
1521O-linkedHMM predict
1528Phosphoserine(CDC2)HMM predict
1613N-linkedHMM predict
1634Phosphoserine(IKK)HMM predict
1676Phosphotyrosine(INSR)HMM predict
1698Phosphothreonine(MAPK)HMM predict
1698Phosphothreonine(CDK)HMM predict
1700Phosphoserine(PKC)HMM predict
1705AsparagineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015080
  • Location:chr11 64130223-64247235
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 64247595 64247805 210 465
CTCF CD4SISSRdata 64247595 64247805 210 465
Fos K562GSE19551 64247166 64247646 480 171
NFkBII GM10847GSE19485 64247073 64248584 1511 593
NFkBII GM12878GSE19485 64247118 64248579 1461 613
NFkBII GM12892GSE19485 64247004 64248609 1605 571
Rb GrowingGSE19898 64247150 64247346 196 13
Rb QuiescentGSE19898 64247159 64247352 193 20
Rb SenescentGSE19898 64247152 64247333 181 7
hScc1 BcellGSE12603 64246494 64247996 1502 10
hScc1 CdLSGSE12603 64247013 64247964 951 253
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 64177240 64177510 270 0
CTCF CD4GSE12889 64212476 64212770 294 0
CTCF CD4SISSRdata 64177240 64177510 270 0
CTCF CD4SISSRdata 64212476 64212770 294 0
CTCF HelaGSE12889 64212541 64212899 358 0
CTCF JurkatGSE12889 64212481 64212849 368 0
ETS1 JurkatGSE17954 64212217 64213237 1020 0
FOXA1 MCF7GSE15244 64205242 64205560 318 0
FOXA1 MCF7GSE15244 64219938 64220866 928 0
FOXA1 MCF7GSE15244 64234313 64235033 720 0
Fos K562GSE19551 64183381 64184448 1067 0
FoxA1 MCF7MACSdata 64220104 64220496 392 0
H3K27me3 colorectalcancer 64168002 64170215 2213 0
H3K27me3 colorectalcancer 64235601 64236182 581 0
H3K27me3 colorectalcancer 64238138 64238972 834 0
H3K27me3 colorectalcancer 64239424 64239731 307 0
H3K27me3 colorectalcancer 64241017 64242448 1431 0
H3K27me3 colorectalcancer 64243435 64243703 268 0
H3K27me3 colorectalcancer 64244176 64245047 871 0
KLF4 hESGSE17917 64175083 64175237 154 0
NFkBII GM12878GSE19485 64238668 64239890 1222 0
NRSF JurkatGSE13047 64238086 64238577 491 0
NRSF-mono JurkatQuESTdata 64238030 64238570 540 0
NRSF pAbJurkat 64179024 64179553 529 0
NRSF pAbJurkat 64191681 64191989 308 0
NRSF pAbJurkat 64195998 64196167 169 0
NRSF pAbJurkat 64208828 64209721 893 0
NRSF pAbJurkat 64229468 64230087 619 0
NRSF pAbJurkat 64235321 64237118 1797 0
NRSF pAbJurkat 64244769 64245252 483 0
NRSF pAbJurkat 64245988 64247751 1763 0
Oct1 HelaGSE14283 64206313 64206351 38 0
P300 T0-glioblastomaGSE21026 64212239 64213047 808 0
P300 T30-glioblastomaGSE21026 64183668 64184470 802 0
P300 T30-glioblastomaGSE21026 64212265 64213172 907 0
Rb QuiescentGSE19898 64209038 64209160 122 0
TAF HelaGSE8489 64220303 64221394 1091 0
TAF HelaGSE8489 64234313 64235033 720 0
TFAP2C MCF7GSE21234 64244641 64244993 352 0
USF1 HepG2E 64176261 64177489 1228 0
hScc1 BcellGSE12603 64173073 64173646 573 0
hScc1 BcellGSE12603 64175095 64175474 379 0
hScc1 BcellGSE12603 64176151 64177667 1516 0
hScc1 BcellGSE12603 64212203 64212974 771 0
hScc1 BcellGSE12603 64218872 64219203 331 0
hScc1 BcellGSE12603 64236660 64237900 1240 0
hScc1 CdLSGSE12603 64173277 64173877 600 0
hScc1 CdLSGSE12603 64174497 64175685 1188 0
hScc1 CdLSGSE12603 64176615 64177631 1016 0
hScc1 CdLSGSE12603 64212203 64212974 771 0
hScc1 CdLSGSE12603 64236840 64238107 1267 0
hScc1 G2GSE9613 64173073 64173646 573 0
hScc1 G2GSE9613 64176189 64177564 1375 0
hScc1 G2GSE9613 64212279 64213248 969 0
hScc1 G2GSE9613 64237228 64238025 797 0
p130 shRbSenescentGSE19898 64183981 64184157 176 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
4662 HTC chr11 64175342 64180357 342 mRNA NRXN2 chr11 64130223 64247236Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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