AutismKB 2.0

Annotation Detail for ARHGAP12


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Basic Information Top
Gene Symbol:ARHGAP12 ( DKFZp779N2050,FLJ10971,FLJ20737,FLJ21785,FLJ45709 )
Gene Full Name: Rho GTPase activating protein 12
Band: 10p11.22
Quick LinksEntrez ID:94134; OMIM: 610577; Uniprot ID:RHG12_HUMAN; ENSEMBL ID: ENSG00000165322; HGNC ID: 16348
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
201Phosphoserine.
206Phosphoserine (By similarity).
213Phosphoserine.
215Phosphoserine.
230Phosphothreonine.
231Phosphothreonine.
240Phosphoserine.
243Phosphotyrosine.
521Phosphothreonine (By similarity).
592Phosphoserine.
Location(AA) Modifications Resource
201Phosphoserine (By similarity).Swiss-Prot 53.0
206Phosphoserine (By similarity).Swiss-Prot 53.0
231Phosphothreonine.Swiss-Prot 53.0
231PhosphothreoninePhospho.ELM 6.0
240Phosphoserine.Swiss-Prot 53.0
240PhosphoserinePhospho.ELM 6.0
243Phosphotyrosine.Swiss-Prot 53.0
243PhosphotyrosinePhospho.ELM 6.0
592Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
16Phosphotyrosine(EGFR)HMM predict
21SulfotyrosineHMM predict
23SulfotyrosineHMM predict
25SulfotyrosineHMM predict
73Phosphothreonine(PKC)HMM predict
90N-linkedHMM predict
161N-linkedHMM predict
165Phosphoserine(MAPK)HMM predict
172N-linkedHMM predict
191PhosphothreonineHMM predict
194Phosphoserine(ATM)HMM predict
194Phosphoserine(CK1)HMM predict
198Phosphoserine(IKK)HMM predict
198PhosphoserineHMM predict
213Phosphoserine(CAMK2)HMM predict
215Phosphoserine(CK2)HMM predict
215Phosphoserine(CK1)HMM predict
220Phosphoserine(CK1)HMM predict
221Phosphoserine(CK1)HMM predict
222Phosphoserine(CK1)HMM predict
222Phosphoserine(CK2)HMM predict
223Phosphoserine(CK1)HMM predict
230O-linkedHMM predict
231Phosphothreonine(CDC2)HMM predict
243Phosphotyrosine(INSR)HMM predict
252Phosphoserine(ATM)HMM predict
262Phosphoserine(IKK)HMM predict
262Phosphoserine(CDC2)HMM predict
283Phosphotyrosine(Syk)HMM predict
319Phosphoserine(CK1)HMM predict
320Phosphoserine(CK1)HMM predict
324SulfotyrosineHMM predict
324Phosphotyrosine(Syk)HMM predict
324Phosphotyrosine(INSR)HMM predict
325SulfotyrosineHMM predict
329SulfotyrosineHMM predict
330Phosphoserine(ATM)HMM predict
330Phosphoserine(IKK)HMM predict
334Phosphoserine(IKK)HMM predict
338Phosphoserine(IKK)HMM predict
338Phosphoserine(CDC2)HMM predict
359Phosphotyrosine(INSR)HMM predict
375SulfotyrosineHMM predict
376Phosphotyrosine(Syk)HMM predict
392N-linkedHMM predict
445N-linkedHMM predict
447Phosphoserine(CK1)HMM predict
448Phosphoserine(CDC2)HMM predict
448O-linkedHMM predict
448Phosphoserine(ATM)HMM predict
448Phosphoserine(IKK)HMM predict
450Phosphoserine(CK1)HMM predict
451Phosphoserine(CDK)HMM predict
451Phosphoserine(CDC2)HMM predict
451Phosphoserine(CDK)HMM predict
460Phosphoserine(CDC2)HMM predict
471N-linkedHMM predict
514N-linkedHMM predict
559N-linkedHMM predict
564N-linkedHMM predict
592Phosphoserine(CDC2)HMM predict
620PhosphoserineHMM predict
620Phosphoserine(CK1)HMM predict
639Phosphothreonine(PKC)HMM predict
639Phosphothreonine(PKA)HMM predict
666N-linkedHMM predict
716N-linkedHMM predict
718Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_018287
  • Location:chr10 32135230-32257775
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 32269041 32270581 1540 12036
ER E2-MCF7GSE14664 32273937 32273974 37 16180
ER Fulvestrant-MCF7GSE14664 32273937 32273976 39 16181
FoxA1 MCF7MACSdata 32265884 32266227 343 8280
FoxA1 MCF7MACSdata 32271764 32272192 428 14203
FoxA1 MCF7MACSdata 32276551 32276831 280 18916
H3K4me2 HCT116GSE10453 32258641 32259456 815 1273
H3ac HepG2E 32257995 32259563 1568 1004
H3ac HepG2E 32270312 32270529 217 12645
Oct1 H2O2-HelaGSE14283 32267759 32267789 30 9999
Oct1 HelaGSE14283 32267760 32267789 29 9999
Oct1 HelaGSE14283 32273933 32273967 34 16175
P300 T30-glioblastomaGSE21026 32269360 32270626 1266 12218
P300 T30-glioblastomaGSE21026 32276249 32277184 935 18941
PHF8 293TGSE20725 32257452 32258418 966 160
PHF8 HeLaGSE20725 32257053 32258530 1477 16
RARA MCF7GSE15244 32258279 32259528 1249 1128
RARA MCF7GSE15244 32269834 32270529 695 12406
RARA MCF7GSE15244 32271641 32272184 543 14137
RARG MCF7GSE15244 32258243 32259528 1285 1110
RARG MCF7GSE15244 32269866 32270529 663 12422
RARG MCF7GSE15244 32271175 32272126 951 13875
TFAP2C MCF7GSE21234 32258175 32258568 393 596
TFAP2C MCF7GSE21234 32264628 32265120 492 7099
TFAP2C MCF7GSE21234 32269766 32270226 460 12221
TFAP2C MCF7GSE21234 32271655 32272295 640 14200
USF1 HepG2E 32257849 32259563 1714 931
USF2 HepG2E 32257975 32259493 1518 959
USF2 HepG2E 32270275 32270529 254 12627
hScc1 CdLSGSE12603 32276493 32276880 387 18911
hScc1 G2GSE9613 32276444 32276880 436 18887
p130 shRbQuiescentGSE19898 32257683 32258480 797 306
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 32134852 32134887 35 361
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 32165868 32165989 121 0
CTCF CD4SISSRdata 32165868 32165989 121 0
ER E2-MCF7GSE14664 32177306 32177339 33 0
H3K4me2 HCT116GSE10453 32256074 32256640 566 0
H3K4me3 colorectalcancer 32255750 32257051 1301 0
H3ac HepG2E 32255787 32257325 1538 0
KLF4 hESGSE17917 32248519 32248678 159 0
Myc K562GSE19551 32165737 32166096 359 0
Myc hESGSE17917 32257585 32257936 351 0
Oct1 H2O2-HelaGSE14283 32144532 32144560 28 0
Oct1 H2O2-HelaGSE14283 32168183 32168235 52 0
Oct1 H2O2-HelaGSE14283 32241934 32241974 40 0
Oct1 HelaGSE14283 32168183 32168219 36 0
Oct1 HelaGSE14283 32241934 32241971 37 0
RARA MCF7GSE15244 32256180 32257051 871 0
RARG MCF7GSE15244 32256213 32257051 838 0
Rb SenescentGSE19898 32198853 32199054 201 0
Stat6 IL-4-hr4GSE17850 32189412 32189744 332 0
TAF k562GSE8489 32178017 32178188 171 0
USF1 HepG2E 32256111 32257051 940 0
VDR GM10855-stimGSE22484 32227846 32229368 1522 0
hScc1 BcellGSE12603 32137566 32137894 328 0
hScc1 BcellGSE12603 32165634 32166029 395 0
hScc1 BcellGSE12603 32191236 32191474 238 0
hScc1 BcellGSE12603 32257289 32257747 458 0
hScc1 CdLSGSE12603 32137566 32138129 563 0
hScc1 CdLSGSE12603 32165598 32166199 601 0
hScc1 CdLSGSE12603 32191128 32191474 346 0
p130 shRbSenescentGSE19898 32193703 32193991 288 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2980 mRNA chr10 32135224 32136649 1419 mRNA ARHGAP12 chr10 32135230 32257776Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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