AutismKB 2.0

Annotation Detail for TJP2


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Basic Information Top
Gene Symbol:TJP2 ( MGC26306,X104,ZO2 )
Gene Full Name: tight junction protein 2 (zona occludens 2)
Band: 9q21.11
Quick LinksEntrez ID:9414; OMIM: 607709; Uniprot ID:ZO2_HUMAN; ENSEMBL ID: ENSG00000119139; HGNC ID: 11828
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
130Phosphoserine.
168Phosphoserine.
170Phosphoserine.
174Phosphoserine.
192Phosphoserine.
244Phosphoserine.
261Phosphotyrosine.
265Phosphotyrosine (By similarity).
266Phosphoserine.
292Phosphoserine (By similarity).
294Phosphoserine (By similarity).
296Phosphoserine.
394Phosphoserine.
398Phosphoserine.
400Phosphoserine.
415Phosphoserine.
426Phosphotyrosine.
440Phosphoserine.
441Phosphoserine.
445Phosphothreonine.
455Phosphothreonine.
574Phosphotyrosine.
702Phosphoserine.
920Phosphoserine.
925Phosphothreonine.
933Phosphothreonine.
966Phosphoserine.
978Phosphoserine.
986Phosphoserine.
1006Phosphoserine (By similarity).
1027Phosphothreonine.
1067Phosphoserine.
1068Phosphoserine.
1118Phosphotyrosine.
1131Phosphothreonine.
1159Phosphoserine.
Location(AA) Modifications Resource
130Phosphoserine.Swiss-Prot 53.0
130PhosphoserinePhospho.ELM 6.0
170Phosphoserine.Swiss-Prot 53.0
170PhosphoserinePhospho.ELM 6.0
174PhosphoserinePhospho.ELM 6.0
192PhosphoserinePhospho.ELM 6.0
192Phosphoserine.Swiss-Prot 53.0
244PhosphoserinePhospho.ELM 6.0
244Phosphoserine.Swiss-Prot 53.0
265Phosphotyrosine (By similarity).Swiss-Prot 53.0
266PhosphoserinePhospho.ELM 6.0
266Phosphoserine.Swiss-Prot 53.0
296PhosphoserinePhospho.ELM 6.0
296Phosphoserine.Swiss-Prot 53.0
394Phosphoserine.Swiss-Prot 53.0
394PhosphoserinePhospho.ELM 6.0
398PhosphoserinePhospho.ELM 6.0
398Phosphoserine.Swiss-Prot 53.0
400PhosphoserinePhospho.ELM 6.0
400Phosphoserine.Swiss-Prot 53.0
415PhosphoserinePhospho.ELM 6.0
430PhosphoserinePhospho.ELM 6.0
431PhosphoserinePhospho.ELM 6.0
440PhosphoserinePhospho.ELM 6.0
440Phosphoserine.Swiss-Prot 53.0
441PhosphoserinePhospho.ELM 6.0
441Phosphoserine.Swiss-Prot 53.0
445PhosphothreoninePhospho.ELM 6.0
445Phosphothreonine.Swiss-Prot 53.0
574Phosphotyrosine.Swiss-Prot 53.0
767PhosphoserinePhospho.ELM 6.0
961PhosphoserinePhospho.ELM 6.0
986PhosphoserinePhospho.ELM 6.0
986Phosphoserine.Swiss-Prot 53.0
1118PhosphotyrosinePhospho.ELM 6.0
1159Phosphoserine.Swiss-Prot 53.0
1159PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
89N-linkedHMM predict
170Phosphoserine(PKA)HMM predict
170Phosphoserine(PKB)HMM predict
170Phosphoserine(IKK)HMM predict
170PhosphoserineHMM predict
186Phosphoserine(PKG)HMM predict
212Phosphothreonine(PKC)HMM predict
216PhosphoserineHMM predict
235MethylarginineHMM predict
249Phosphotyrosine(Syk)HMM predict
249Phosphotyrosine(EGFR)HMM predict
257Phosphotyrosine(Syk)HMM predict
261Phosphotyrosine(INSR)HMM predict
265Phosphotyrosine(INSR)HMM predict
287MethylarginineHMM predict
292O-linkedHMM predict
294Phosphoserine(CDC2)HMM predict
296Phosphoserine(CDC2)HMM predict
300MethylarginineHMM predict
354N-linkedHMM predict
360N-linkedHMM predict
396N-linkedHMM predict
398Phosphoserine(ATM)HMM predict
398Phosphoserine(CK1)HMM predict
400Phosphoserine(CK2)HMM predict
400Phosphoserine(CK1)HMM predict
400Phosphoserine(CK2)HMM predict
406Phosphoserine(CK2)HMM predict
411N-linkedHMM predict
415Phosphoserine(CDC2)HMM predict
423SulfotyrosineHMM predict
423Phosphotyrosine(SRC)HMM predict
423Phosphotyrosine(Syk)HMM predict
426SulfotyrosineHMM predict
428SulfotyrosineHMM predict
445Phosphothreonine(CDK)HMM predict
445Phosphothreonine(MAPK)HMM predict
455Phosphothreonine(MAPK)HMM predict
457Phosphothreonine(MAPK)HMM predict
457Phosphothreonine(CDK)HMM predict
479Phosphotyrosine(EGFR)HMM predict
499PhosphoserineHMM predict
506SulfotyrosineHMM predict
619Phosphothreonine(CDK)HMM predict
661N-linkedHMM predict
778Phosphothreonine(PKC)HMM predict
802N-linkedHMM predict
829N-linkedHMM predict
833N-linkedHMM predict
864N-linkedHMM predict
920Phosphoserine(CK2)HMM predict
932Phosphotyrosine(INSR)HMM predict
978Phosphoserine(CAMK2)HMM predict
1025N-linkedHMM predict
1027Phosphothreonine(MAPK)HMM predict
1031O-linkedHMM predict
1054Phosphothreonine(CDC2)HMM predict
1131Phosphothreonine(CDC2)HMM predict
1131Phosphothreonine(CDK)HMM predict
1131Phosphothreonine(MAPK)HMM predict
1135O-linkedHMM predict
1136O-linkedHMM predict
1137O-linkedHMM predict
1147Phosphoserine(PKA)HMM predict
1147PhosphoserineHMM predict
1159Phosphoserine(CK2)HMM predict
1166Phosphotyrosine(Syk)HMM predict
1166Phosphotyrosine(EGFR)HMM predict
1166Phosphotyrosine(Abl)HMM predict
1174Phosphoserine(CK1)HMM predict
1178Phosphotyrosine(Syk)HMM predict
1185Phosphotyrosine(EGFR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004817
  • Location:chr9 70978908-71059937
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 70973735 70974024 289 5029
Oct1 HelaGSE14283 70958975 70959005 30 19919
TFAP2C MCF7GSE21234 70960080 70960336 256 18701
hScc1 BcellGSE12603 70970363 70970579 216 8438
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 70997931 70998180 249 0
CTCF CD4SISSRdata 70997931 70998180 249 0
CTCF HelaGSE12889 71028359 71028575 216 0
CTCF JurkatGSE12889 71028390 71028541 151 0
FOXA1 MCF7GSE15244 70983000 70983663 663 0
FOXA1 MCF7GSE15244 70985051 70985840 789 0
Fos K562GSE19551 70985130 70985781 651 0
FoxA1 MCF7MACSdata 70983205 70983530 325 0
FoxA1 MCF7MACSdata 70985417 70985711 294 0
Gata2 K562GSE18868 70985294 70985900 606 0
Gata2 K562GSE18868 70993600 70994234 634 0
Gata2 K562GSE18868 71020544 71021027 483 0
Gata2 K562GSE18868 71028235 71028603 368 0
H3ac HepG2E 70979102 70980870 1768 0
Myc K562GSE19551 70985404 70985727 323 0
Myc K562GSE19551 71028249 71028632 383 0
NFkBII GM12878GSE19485 70979017 70982114 3097 0
Nanog hESGSE18292 71016791 71017260 469 0
Oct1 H2O2-HelaGSE14283 71053747 71053781 34 0
Oct1 HelaGSE14283 71004735 71004771 36 0
Oct1 HelaGSE14283 71053747 71053776 29 0
Rb SenescentGSE19898 70979033 70979582 549 0
Rb shRbSenescenceGSE19898 70979060 70979251 191 0
Stat6 IL-4-hr4GSE17850 71020969 71021417 448 0
TAF k562GSE8489 70979388 70980263 875 0
TFAP2C MCF7GSE21234 71002491 71003044 553 0
hScc1 BcellGSE12603 70997967 70998577 610 0
p130 SenescentGSE19898 70979097 70979764 667 0
p63 keratinocytesGSE17611 71057744 71058302 558 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
247 Unknown MicroArray miR-124 TJP2 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000119139 G1-to-S transition n_a n_a "epithelium, lymphoblast, lymphocyte, squamous cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma, tumour"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
26557 mRNA TJP2 chr9 69018642 69099672 1521 mRNA chr9 69093165 69099672Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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