AutismKB 2.0

Annotation Detail for NRG2


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Basic Information Top
Gene Symbol:NRG2 ( DON1,HRG2,NTAK )
Gene Full Name: neuregulin 2
Band: 5q31.2
Quick LinksEntrez ID:9542; OMIM: 603818; Uniprot ID:NRG2_HUMAN; ENSEMBL ID: ENSG00000158458; HGNC ID: 7998
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
52N-linked (GlcNAc...) (Potential).
53N-linked (GlcNAc...) (Potential).
147N-linked (GlcNAc...) (Potential).
278N-linked (GlcNAc...) (Potential).
346N-linked (GlcNAc...) (Potential).
809Phosphoserine (By similarity).
Location(AA) Modifications Resource
52N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
53N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
147N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
278N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
346N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
809Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
16O-linkedHMM predict
21Phosphoserine(PKC)HMM predict
21Phosphoserine(IKK)HMM predict
21Phosphoserine(PKB)HMM predict
29Phosphoserine(CK1)HMM predict
35Phosphoserine(IKK)HMM predict
35Phosphoserine(CK1)HMM predict
40Phosphoserine(CK1)HMM predict
41Phosphoserine(CK1)HMM predict
43Phosphoserine(IKK)HMM predict
45Phosphoserine(CK1)HMM predict
49Phosphoserine(CK1)HMM predict
50Phosphoserine(CK1)HMM predict
51Phosphoserine(IKK)HMM predict
51Phosphoserine(PKB)HMM predict
52N-linkedHMM predict
53N-linkedHMM predict
55Phosphoserine(CK1)HMM predict
75Phosphoserine(IKK)HMM predict
75Phosphoserine(CDC2)HMM predict
86MethylarginineHMM predict
147N-linkedHMM predict
155O-linkedHMM predict
294Phosphoserine(PKG)HMM predict
309Phosphotyrosine(Jak)HMM predict
309Phosphotyrosine(INSR)HMM predict
332O-linkedHMM predict
334O-linkedHMM predict
346N-linkedHMM predict
494O-linkedHMM predict
496O-linkedHMM predict
498Phosphoserine(IKK)HMM predict
500Phosphoserine(ATM)HMM predict
506O-linkedHMM predict
507O-linkedHMM predict
509Phosphothreonine(MAPK)HMM predict
528Phosphoserine(CK1)HMM predict
528Phosphoserine(IKK)HMM predict
531Phosphoserine(CK1)HMM predict
533Phosphoserine(ATM)HMM predict
545Phosphoserine(IKK)HMM predict
572Phosphothreonine(PKA)HMM predict
572Phosphothreonine(PKG)HMM predict
592Phosphotyrosine(EGFR)HMM predict
598Phosphothreonine(MAPK)HMM predict
598Phosphothreonine(CDK)HMM predict
630O-linkedHMM predict
674SulfotyrosineHMM predict
677SulfotyrosineHMM predict
678Phosphotyrosine(Syk)HMM predict
690Phosphothreonine(PKA)HMM predict
703Phosphoserine(CDC2)HMM predict
703Phosphoserine(CDK)HMM predict
713Phosphotyrosine(INSR)HMM predict
713SulfotyrosineHMM predict
713Phosphotyrosine(Syk)HMM predict
713Phosphotyrosine(EGFR)HMM predict
728MethylarginineHMM predict
730MethylarginineHMM predict
736Phosphothreonine(PKA)HMM predict
737Phosphoserine(PKG)HMM predict
746Phosphoserine(PKG)HMM predict
762O-linkedHMM predict
762Phosphoserine(IKK)HMM predict
764Phosphoserine(CK1)HMM predict
777Phosphoserine(CK2)HMM predict
809Phosphoserine(IKK)HMM predict
821Phosphotyrosine(Syk)HMM predict
838GlycineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004883
  • Location:chr5 139207443-139403062
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K27me3 colorectalcancer 139403411 139405108 1697 1197
Oct1 HelaGSE14283 139418097 139418151 54 15062
Rb SenescentGSE19898 139403130 139403351 221 178
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 139223913 139224129 216 0
CTCF CD4GSE12889 139328509 139328913 404 0
CTCF CD4SISSRdata 139223913 139224129 216 0
CTCF CD4SISSRdata 139328509 139328913 404 0
CTCF G2GSE9613 139207747 139207978 231 0
CTCF G2GSE9613 139208292 139208440 148 0
CTCF G2GSE9613 139209195 139209395 200 0
CTCF G2GSE9613 139212112 139212757 645 0
CTCF G2GSE9613 139215537 139216945 1408 0
CTCF G2GSE9613 139218708 139219279 571 0
CTCF G2GSE9613 139222321 139222807 486 0
CTCF G2GSE9613 139223371 139223668 297 0
CTCF G2GSE9613 139228166 139228643 477 0
CTCF G2GSE9613 139229301 139229646 345 0
CTCF G2GSE9613 139231449 139231883 434 0
CTCF G2GSE9613 139232823 139233673 850 0
CTCF G2GSE9613 139236957 139237682 725 0
CTCF G2GSE9613 139242699 139243052 353 0
CTCF G2GSE9613 139245032 139245326 294 0
CTCF G2GSE9613 139253676 139253993 317 0
CTCF G2GSE9613 139254864 139255197 333 0
CTCF G2GSE9613 139263845 139264475 630 0
CTCF G2GSE9613 139264959 139265379 420 0
CTCF G2GSE9613 139270807 139271325 518 0
CTCF G2GSE9613 139315887 139316098 211 0
CTCF G2GSE9613 139327787 139329027 1240 0
CTCF G2GSE9613 139335105 139335284 179 0
CTCF G2GSE9613 139401598 139402051 453 0
CTCF G2GSE9613 139402410 139402955 545 0
ER Fulvestrant-MCF7GSE14664 139248683 139248734 51 0
H3K27me3 colorectalcancer 139400631 139401674 1043 0
Myc K562GSE19551 139328524 139328982 458 0
NFkBII GM12878GSE19485 139397818 139401950 4132 0
NFkBII GM12892GSE19485 139398028 139400276 2248 0
NRSF JurkatGSE13047 139334028 139334344 316 0
NRSF JurkatGSE13047 139334385 139335036 651 0
NRSF JurkatSISSRdata 139334408 139334790 382 0
NRSF mAbJurkat 139330937 139331315 378 0
NRSF mAbJurkat 139333800 139335387 1587 0
NRSF mAbJurkat 139337056 139337220 164 0
NRSF-mono JurkatQuESTdata 139334383 139334908 525 0
NRSF pAbJurkat 139339802 139340040 238 0
NRSF pAbJurkat 139402375 139402986 611 0
NRSF-poly JurkatQuESTdata 139334370 139334959 589 0
Oct1 H2O2-HelaGSE14283 139283694 139283721 27 0
Oct1 H2O2-HelaGSE14283 139344281 139344319 38 0
Oct1 HelaGSE14283 139209162 139209211 49 0
Oct1 HelaGSE14283 139248460 139248514 54 0
Oct1 HelaGSE14283 139258589 139258657 68 0
Oct1 HelaGSE14283 139262898 139262927 29 0
Oct1 HelaGSE14283 139283687 139283755 68 0
Oct1 HelaGSE14283 139291050 139291087 37 0
Oct1 HelaGSE14283 139312867 139312893 26 0
Oct1 HelaGSE14283 139344281 139344336 55 0
Oct1 HelaGSE14283 139364679 139364762 83 0
Oct1 HelaGSE14283 139390194 139390223 29 0
RNAII Tamoxifen-MCF7GSE14664 139344278 139344334 56 0
Rb SenescentGSE19898 139328593 139328859 266 0
Rb shRbQuiescentGSE19898 139328581 139328809 228 0
STAT1 IFNSISSRdata 139328543 139329027 484 0
TFAP2C MCF7GSE21234 139233080 139233623 543 0
TFAP2C MCF7GSE21234 139256472 139257021 549 0
VDR GM10861-stimGSE22484 139320151 139322154 2003 0
VDR GM10861-stimGSE22484 139328283 139329423 1140 0
hScc1 BcellGSE12603 139207498 139207978 480 0
hScc1 BcellGSE12603 139263518 139264088 570 0
hScc1 BcellGSE12603 139310618 139310757 139 0
hScc1 BcellGSE12603 139328116 139329027 911 0
hScc1 BcellGSE12603 139341188 139341476 288 0
hScc1 BcellGSE12603 139402410 139403039 629 0
hScc1 CdLSGSE12603 139207747 139207978 231 0
hScc1 CdLSGSE12603 139328150 139329027 877 0
hScc1 G2GSE9613 139207747 139207978 231 0
hScc1 G2GSE9613 139327787 139329027 1240 0
p63 keratinocytesGSE17611 139345207 139346278 1071 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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