AutismKB 2.0

Annotation Detail for CLOCK


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Basic Information Top
Gene Symbol:CLOCK ( KAT13D,KIAA0334,bHLHe8 )
Gene Full Name: clock homolog (mouse)
Band: 4q12
Quick LinksEntrez ID:9575; OMIM: 601851; Uniprot ID:CLOCK_HUMAN; ENSEMBL ID: ENSG00000134852; HGNC ID: 2082
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
331Phosphotyrosine.
408Phosphoserine (By similarity).
Location(AA) Modifications Resource
408Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
133Phosphotyrosine(INSR)HMM predict
135O-linkedHMM predict
140Phosphoserine(CK1)HMM predict
210Phosphotyrosine(Syk)HMM predict
210Phosphotyrosine(Abl)HMM predict
210Phosphotyrosine(SRC)HMM predict
224Phosphoserine(CK1)HMM predict
224Phosphoserine(IKK)HMM predict
226Phosphoserine(CK2)HMM predict
277Phosphothreonine(PKC)HMM predict
281Phosphoserine(CK1)HMM predict
312SulfotyrosineHMM predict
313Phosphotyrosine(Syk)HMM predict
403Phosphoserine(IKK)HMM predict
403Phosphoserine(ATM)HMM predict
406Phosphoserine(IKK)HMM predict
408Phosphoserine(CK1)HMM predict
429Phosphothreonine(MAPK)HMM predict
429Phosphothreonine(CDK)HMM predict
440Phosphoserine(CK1)HMM predict
440Phosphoserine(CK2)HMM predict
441Phosphoserine(PKG)HMM predict
441Phosphoserine(PKA)HMM predict
449O-linkedHMM predict
449O-linkedHMM predict
451Phosphothreonine(MAPK)HMM predict
457O-linkedHMM predict
459O-linkedHMM predict
461Phosphothreonine(CDC2)HMM predict
461Phosphothreonine(MAPK)HMM predict
461Phosphothreonine(CDK)HMM predict
479Phosphoserine(PKB)HMM predict
479Phosphoserine(IKK)HMM predict
479Phosphoserine(PKG)HMM predict
479Phosphoserine(PKA)HMM predict
482Phosphoserine(IKK)HMM predict
484Phosphoserine(IKK)HMM predict
487Phosphoserine(ATM)HMM predict
492Phosphoserine(CK1)HMM predict
493Phosphoserine(IKK)HMM predict
585N-linkedHMM predict
588N-linkedHMM predict
631O-linkedHMM predict
641Phosphoserine(CK1)HMM predict
644Phosphoserine(ATM)HMM predict
647O-linkedHMM predict
648Phosphoserine(IKK)HMM predict
651Phosphoserine(ATM)HMM predict
656O-linkedHMM predict
662Phosphotyrosine(Abl)HMM predict
668Phosphoserine(ATM)HMM predict
685N-linkedHMM predict
748Phosphoserine(IKK)HMM predict
752Phosphoserine(IKK)HMM predict
752Phosphoserine(CK1)HMM predict
754O-linkedHMM predict
762Phosphoserine(CK1)HMM predict
795N-linkedHMM predict
834Phosphothreonine(PKA)HMM predict
836Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004898
  • Location:chr4 55993416-56107753
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 56107738 56107948 210 90
CTCF CD4SISSRdata 56107738 56107948 210 90
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 56005893 56006020 127 0
CTCF CD4SISSRdata 56005893 56006020 127 0
CTCF G2GSE9613 55995947 55996478 531 0
CTCF G2GSE9613 56106636 56108199 1563 0
Fos K562GSE19551 56063963 56064479 516 0
H3K4me3 colorectalcancer 56106372 56106828 456 0
H3ac HepG2E 56105003 56105799 796 0
H3ac HepG2E 56106404 56106787 383 0
Oct1 H2O2-HelaGSE14283 56016791 56016818 27 0
Oct1 HelaGSE14283 56054890 56054922 32 0
PHF8 HeLaGSE20725 56106389 56108580 2191 0
TAF HelaGSE8489 56106489 56106905 416 0
hScc1 BcellGSE12603 56106709 56108199 1490 0
hScc1 G2GSE9613 56106672 56108345 1673 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-132 hsa-mir-132 17 17553428
hsa-miR-132* hsa-mir-132 17 17553428
hsa-miR-181d hsa-mir-181d 19 19478556
hsa-miR-191 hsa-mir-191 3 19478556
hsa-miR-191* hsa-mir-191 3 19478556
hsa-miR-194 hsa-mir-194-1 1 19682069
hsa-miR-194 hsa-mir-194-2 11 19682069
hsa-miR-219-1-3p hsa-mir-219-1 6 17553428
hsa-miR-219-2-3p hsa-mir-219-2 9 17553428
hsa-miR-219-5p hsa-mir-219-1 6 17553428
hsa-miR-219-5p hsa-mir-219-2 9 17553428
hsa-miR-26a hsa-mir-26a-1 3 19608742
hsa-miR-26a hsa-mir-26a-2 12 19608742
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
462 mRNA repression TRUE miR-141 CLOCK in vitro reporter gene assay (Luciferase) 15131085
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000134852 n_a n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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