Annotation Detail for MTRF1

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Basic Information Top

Gene Symbol:	MTRF1 ( MGC47721,MRF1,MTTRF1,RF1 )
Gene Full Name:	mitochondrial translational release factor 1
Band:	13q14.11
Quick Links	Entrez ID:9617; OMIM: 604601; Uniprot ID:RF1M_HUMAN; ENSEMBL ID: ENSG00000120662; HGNC ID: 7469
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

No data

Location(AA)	Modification	Resource
56	N-linked	HMM predict
86	Phosphotyrosine(Syk)	HMM predict
158	Phosphothreonine(PKC)	HMM predict
213	N-linked	HMM predict
226	N-linked	HMM predict
227	Phosphotyrosine(INSR)	HMM predict
232	Sulfotyrosine	HMM predict
316	N-linked	HMM predict
387	Phosphothreonine(PKC)	HMM predict
389	N-linked	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_004294
Location:chr13 40688516-40735712
strand:-

Upstream the gene:12 results
Downstream the gene:3 results
Inside the gene:19 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
ER	E2-MCF7	GSE14664	40739479	40739541	62	3798
ER	E2-MCF7	GSE14664	40749090	40749154	64	13410
ER	E2-MCF7	GSE14664	40753143	40753238	95	17478
ER	Fulvestrant-MCF7	GSE14664	40736107	40736142	35	412
ER	Fulvestrant-MCF7	GSE14664	40753152	40753243	91	17485
ETS1	Jurkat	GSE17954	40735118	40736574	1456	134
Oct1	H2O2-Hela	GSE14283	40741406	40741459	53	5720
Oct1	H2O2-Hela	GSE14283	40749218	40749245	27	13519
Oct1	Hela	GSE14283	40749193	40749276	83	13522
Oct1	Hela	GSE14283	40749367	40749418	51	13680
P300	T30-glioblastoma	GSE21026	40735077	40736471	1394	62
TAFII	hES	GSE17917	40735630	40735808	178	7

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	H2O2-Hela	GSE14283	40687133	40687166	33	1367
Oct1	Hela	GSE14283	40687133	40687172	39	1364
TFAP2C	MCF7	GSE21234	40685339	40686278	939	2708

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	40694413	40694668	255	0
CTCF	CD4	SISSRdata	40694413	40694668	255	0
CTCF	G2	GSE9613	40694290	40694497	207	0
ER	E2-MCF7	GSE14664	40734111	40734268	157	0
ER	Fulvestrant-MCF7	GSE14664	40730175	40730214	39	0
ER	Fulvestrant-MCF7	GSE14664	40730911	40730969	58	0
ER	Fulvestrant-MCF7	GSE14664	40731818	40731850	32	0
ER	Fulvestrant-MCF7	GSE14664	40734128	40734277	149	0
ER	Fulvestrant-MCF7	GSE14664	40735163	40735247	84	0
GABP	Hela	GSE8489	40735027	40735858	831	0
GABP	k562	GSE8489	40734955	40735786	831	0
H3K4me3	colorectal	cancer	40735027	40735555	528	0
H3ac	HepG2	E	40734673	40735596	923	0
Oct1	Hela	GSE14283	40695686	40695713	27	0
PHF8	293T	GSE20725	40735170	40736061	891	0
RARA	MCF7	GSE15244	40735166	40735670	504	0
hScc1	Bcell	GSE12603	40694290	40694497	207	0
hScc1	CdLS	GSE12603	40694219	40694497	278	0
p63	keratinocytes	GSE17611	40732183	40732980	797	0

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
7114	mRNA		chr13	40690721	40692134	1413	mRNA	MTRF1	chr13	40688515	40735713	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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