AutismKB 2.0

Annotation Detail for ARHGEF10


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Basic Information Top
Gene Symbol:ARHGEF10 ( DKFZp686H0726,GEF10,MGC131664 )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 10
Band: 8p23.3
Quick LinksEntrez ID:9639; OMIM: 608136; Uniprot ID:ARHGA_HUMAN; ENSEMBL ID: ENSG00000104728; HGNC ID: 14103
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
379Phosphoserine (By similarity).
1284Phosphoserine.
1287Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
72Phosphoserine(IKK)HMM predict
82O-linkedHMM predict
99O-linkedHMM predict
99Phosphothreonine(MAPK)HMM predict
99O-linkedHMM predict
131Phosphothreonine(MAPK)HMM predict
131O-linkedHMM predict
157Phosphotyrosine(Syk)HMM predict
172Phosphoserine(CDC2)HMM predict
180Phosphoserine(CK2)HMM predict
198Phosphoserine(IKK)HMM predict
200Phosphoserine(CK1)HMM predict
201O-linkedHMM predict
239Phosphotyrosine(Syk)HMM predict
239SulfotyrosineHMM predict
239Phosphotyrosine(EGFR)HMM predict
239Phosphotyrosine(SRC)HMM predict
247Phosphoserine(CK1)HMM predict
249Phosphoserine(CK1)HMM predict
249Phosphoserine(CK2)HMM predict
256SulfotyrosineHMM predict
256Phosphotyrosine(EGFR)HMM predict
256Phosphotyrosine(SRC)HMM predict
256Phosphotyrosine(Syk)HMM predict
281PhosphoserineHMM predict
281Phosphoserine(CK2)HMM predict
282SulfotyrosineHMM predict
282Phosphotyrosine(Syk)HMM predict
288Phosphoserine(IKK)HMM predict
373PhosphoserineHMM predict
388Phosphoserine(CK1)HMM predict
409Phosphothreonine(MAPK)HMM predict
550Phosphoserine(CDC2)HMM predict
580N-linkedHMM predict
691Phosphoserine(ATM)HMM predict
716Phosphothreonine(PKC)HMM predict
743Phosphotyrosine(Syk)HMM predict
781N-linkedHMM predict
909N-linkedHMM predict
911Phosphoserine(ATM)HMM predict
915Phosphoserine(IKK)HMM predict
942N-linkedHMM predict
1005Phosphoserine(CDC2)HMM predict
1006Phosphoserine(ATM)HMM predict
1024Phosphothreonine(PKC)HMM predict
1232Phosphoserine(PKG)HMM predict
1258Phosphoserine(ATM)HMM predict
1282Phosphoserine(CK1)HMM predict
1282Phosphoserine(CK2)HMM predict
1283Phosphoserine(CK1)HMM predict
1287Phosphoserine(IKK)HMM predict
1307SulfotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014629
  • Location:chr8 1759555-1894212
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 1747449 1747834 385 11914
CTCF G2GSE9613 1751747 1752559 812 7403
CTCF G2GSE9613 1758908 1759145 237 529
FOXA1 MCF7GSE15244 1751747 1752256 509 7554
Fos K562GSE19551 1759110 1759611 501 195
Nanog hESGSE18292 1749777 1750014 237 9660
P300 T30-glioblastomaGSE21026 1758959 1759801 842 176
PHF8 HeLaGSE20725 1758420 1760108 1688 292
Rb shRbQuiescentGSE19898 1755066 1755302 236 4372
Sox2 hESGSE18292 1749599 1750013 414 9750
p130 shRbSenescentGSE19898 1759359 1759561 202 96
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 1895519 1895741 222 1418
CTCF G2GSE9613 1897454 1898180 726 3605
CTCF G2GSE9613 1898752 1899480 728 4904
CTCF G2GSE9613 1901267 1901706 439 7274
NRSF pAbJurkat 1895274 1895741 467 1295
NRSF pAbJurkat 1897454 1898009 555 3519
TFAP2C MCF7GSE21234 1898579 1899211 632 4683
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 1884286 1888627 4341 0
CBP T0-glioblastomaGSE21026 1861830 1862233 403 0
CTCF CD4GSE12889 1828024 1828261 237 0
CTCF CD4SISSRdata 1828024 1828261 237 0
CTCF G2GSE9613 1759398 1760258 860 0
CTCF G2GSE9613 1766497 1767485 988 0
CTCF G2GSE9613 1769410 1770055 645 0
CTCF G2GSE9613 1770576 1771437 861 0
CTCF G2GSE9613 1774695 1776092 1397 0
CTCF G2GSE9613 1777663 1778083 420 0
CTCF G2GSE9613 1779791 1780156 365 0
CTCF G2GSE9613 1784886 1786157 1271 0
CTCF G2GSE9613 1788499 1788780 281 0
CTCF G2GSE9613 1789606 1789961 355 0
CTCF G2GSE9613 1805375 1805510 135 0
CTCF G2GSE9613 1810244 1810540 296 0
CTCF G2GSE9613 1816681 1817395 714 0
CTCF G2GSE9613 1832977 1833229 252 0
CTCF G2GSE9613 1833528 1834033 505 0
CTCF G2GSE9613 1837094 1837434 340 0
CTCF G2GSE9613 1844843 1845156 313 0
CTCF G2GSE9613 1847756 1848004 248 0
CTCF G2GSE9613 1851418 1851786 368 0
CTCF G2GSE9613 1854364 1855667 1303 0
CTCF G2GSE9613 1873436 1873663 227 0
CTCF G2GSE9613 1879632 1879908 276 0
CTCF G2GSE9613 1892473 1892796 323 0
E2F4 G0GSE7516 1774245 1776124 1879 0
ER Breast-CancerGSE22609 1818668 1819311 643 0
FOXA1 MCF7GSE15244 1766249 1767780 1531 0
FOXA1 MCF7GSE15244 1774098 1776330 2232 0
FOXA1 MCF7GSE15244 1785815 1786157 342 0
FOXA1 MCF7GSE15244 1854364 1855735 1371 0
FoxA1 MCF7MACSdata 1797843 1798028 185 0
NRSF pAbJurkat 1759740 1760258 518 0
NRSF pAbJurkat 1761034 1761285 251 0
NRSF pAbJurkat 1769068 1769377 309 0
NRSF pAbJurkat 1774695 1776330 1635 0
NRSF pAbJurkat 1779669 1780084 415 0
NRSF pAbJurkat 1800925 1801236 311 0
NRSF pAbJurkat 1854364 1855853 1489 0
NRSF pAbJurkat 1879632 1879908 276 0
P300 T30-glioblastomaGSE21026 1830333 1831117 784 0
TAF k562GSE8489 1774513 1776257 1744 0
TFAP2C MCF7GSE21234 1767259 1767746 487 0
hScc1 BcellGSE12603 1769068 1769457 389 0
hScc1 BcellGSE12603 1792353 1792587 234 0
hScc1 BcellGSE12603 1833191 1833883 692 0
hScc1 BcellGSE12603 1867585 1867793 208 0
hScc1 BcellGSE12603 1879592 1879878 286 0
hScc1 CdLSGSE12603 1825441 1826060 619 0
hScc1 CdLSGSE12603 1827817 1828640 823 0
p130 QuiescentGSE19898 1873681 1873929 248 0
p130 G0GSE7516 1774739 1776187 1448 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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