AutismKB 2.0

Annotation Detail for DOCK4


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Basic Information Top
Gene Symbol:DOCK4 ( FLJ34238,KIAA0716,MGC134911,MGC134912 )
Gene Full Name: dedicator of cytokinesis 4
Band: 7q31.1
Quick LinksEntrez ID:9732; OMIM: 607679; Uniprot ID:DOCK4_HUMAN; ENSEMBL ID: ENSG00000128512; HGNC ID: 19192
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
167Phosphotyrosine (By similarity).
1614Phosphoserine.
1618Phosphoserine.
1620Phosphoserine.
1794SH3-binding (Potential).
1831Phosphotyrosine.
Location(AA) Modifications Resource
1620Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
147Phosphothreonine(PKA)HMM predict
167Phosphotyrosine(Syk)HMM predict
193Phosphothreonine(PKA)HMM predict
273Phosphotyrosine(EGFR)HMM predict
273Phosphotyrosine(Jak)HMM predict
349N-linkedHMM predict
354N-linkedHMM predict
405Phosphotyrosine(Jak)HMM predict
405Phosphotyrosine(INSR)HMM predict
462N-linkedHMM predict
463N-linkedHMM predict
542Phosphotyrosine(Jak)HMM predict
753Phosphoserine(IKK)HMM predict
757Phosphoserine(ATM)HMM predict
759Phosphoserine(ATM)HMM predict
821Phosphotyrosine(INSR)HMM predict
821Phosphotyrosine(Syk)HMM predict
865N-linkedHMM predict
870Phosphoserine(CK1)HMM predict
927Phosphothreonine(PKC)HMM predict
931SulfotyrosineHMM predict
1001SulfotyrosineHMM predict
1028Phosphoserine(CDK)HMM predict
1127Phosphotyrosine(Syk)HMM predict
1127Phosphotyrosine(EGFR)HMM predict
1150O-linkedHMM predict
1199Phosphotyrosine(EGFR)HMM predict
1215N-linkedHMM predict
1286SulfotyrosineHMM predict
1342Phosphotyrosine(INSR)HMM predict
1342Phosphotyrosine(EGFR)HMM predict
1426Phosphothreonine(PKA)HMM predict
1520Phosphotyrosine(EGFR)HMM predict
1605N-linkedHMM predict
1618Phosphoserine(IKK)HMM predict
1620Phosphoserine(CDC2)HMM predict
1620Phosphoserine(IKK)HMM predict
1645Phosphoserine(CK1)HMM predict
1647Phosphoserine(CK2)HMM predict
1648Phosphoserine(ATM)HMM predict
1656N-linkedHMM predict
1664Phosphoserine(CK1)HMM predict
1664Phosphoserine(ATM)HMM predict
1673Phosphoserine(CDK)HMM predict
1675O-linkedHMM predict
1677O-linkedHMM predict
1678Phosphoserine(CK1)HMM predict
1678Phosphoserine(IKK)HMM predict
1680Phosphoserine(CK1)HMM predict
1682O-linkedHMM predict
1684Phosphoserine(IKK)HMM predict
1688N-linkedHMM predict
1690O-linkedHMM predict
1692O-linkedHMM predict
1695Phosphoserine(CDC2)HMM predict
1700Phosphoserine(MAPK)HMM predict
1700Phosphoserine(IKK)HMM predict
1704Phosphoserine(ATM)HMM predict
1714Phosphoserine(IKK)HMM predict
1717Phosphoserine(CDC2)HMM predict
1762N-linkedHMM predict
1764Phosphothreonine(MAPK)HMM predict
1766O-linkedHMM predict
1767Phosphoserine(IKK)HMM predict
1769Phosphoserine(IKK)HMM predict
1787Phosphoserine(MAPK)HMM predict
1795O-linkedHMM predict
1795O-linkedHMM predict
1797O-linkedHMM predict
1797O-linkedHMM predict
1799O-linkedHMM predict
1799Phosphoserine(CDC2)HMM predict
1804O-linkedHMM predict
1806O-linkedHMM predict
1808Phosphoserine(CDC2)HMM predict
1808Phosphoserine(CDK)HMM predict
1808PhosphoserineHMM predict
1810Phosphoserine(CDC2)HMM predict
1810Phosphoserine(CDK)HMM predict
1815Phosphoserine(CDC2)HMM predict
1825Phosphothreonine(MAPK)HMM predict
1827Phosphoserine(CDC2)HMM predict
1853O-linkedHMM predict
1897Phosphoserine(PKG)HMM predict
1899Phosphothreonine(MAPK)HMM predict
1903Phosphotyrosine(SRC)HMM predict
1909Phosphothreonine(PKC)HMM predict
1919Phosphoserine(IKK)HMM predict
1926O-linkedHMM predict
1950Phosphothreonine(PKA)HMM predict
1960ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014705
  • Location:chr7 111153400-111633697
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 111632732 111634715 1983 26
Rb SenescentGSE19898 111633511 111634011 500 64
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 111136727 111137109 382 16483
Oct1 HelaGSE14283 111147517 111147559 42 5863
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 111540825 111541074 249 0
CTCF CD4GSE12889 111162894 111163261 367 0
CTCF CD4GSE12889 111168981 111169400 419 0
CTCF CD4SISSRdata 111162894 111163261 367 0
CTCF CD4SISSRdata 111168981 111169400 419 0
CTCF G2GSE9613 111157646 111158165 519 0
CTCF G2GSE9613 111162896 111163526 630 0
CTCF G2GSE9613 111168864 111169438 574 0
CTCF G2GSE9613 111179576 111179814 238 0
CTCF G2GSE9613 111184159 111184435 276 0
CTCF G2GSE9613 111190373 111190616 243 0
CTCF G2GSE9613 111280540 111280927 387 0
CTCF G2GSE9613 111282262 111283375 1113 0
CTCF G2GSE9613 111358344 111358512 168 0
CTCF G2GSE9613 111537917 111538061 144 0
CTCF G2GSE9613 111632479 111633845 1366 0
ER E2-MCF7GSE14664 111566870 111566904 34 0
FOXA1 MCF7GSE15244 111587582 111588458 876 0
FoxA1 MCF7MACSdata 111587386 111587613 227 0
H3K4me2 HCT116GSE10453 111631966 111632614 648 0
H3K4me3 colorectalcancer 111631441 111632898 1457 0
H3ac HepG2E 111630797 111633142 2345 0
NFkBII GM12878GSE19485 111483179 111484615 1436 0
NFkBII GM12892GSE19485 111483267 111484363 1096 0
Nanog hESGSE18292 111170326 111170956 630 0
Nanog hESGSE18292 111279478 111280220 742 0
Oct1 H2O2-HelaGSE14283 111350143 111350182 39 0
Oct1 H2O2-HelaGSE14283 111531551 111531583 32 0
Oct1 H2O2-HelaGSE14283 111545518 111545550 32 0
Oct1 HelaGSE14283 111204069 111204115 46 0
Oct1 HelaGSE14283 111204234 111204265 31 0
Oct1 HelaGSE14283 111262199 111262230 31 0
Oct1 HelaGSE14283 111350101 111350182 81 0
Oct1 HelaGSE14283 111354956 111354988 32 0
Oct1 HelaGSE14283 111373664 111373701 37 0
Oct1 HelaGSE14283 111379114 111379141 27 0
Oct1 HelaGSE14283 111446814 111446842 28 0
Oct1 HelaGSE14283 111532298 111532334 36 0
Oct1 HelaGSE14283 111545512 111545557 45 0
Oct1 HelaGSE14283 111604149 111604183 34 0
P300 T0-glioblastomaGSE21026 111540862 111541071 209 0
RARA MCF7GSE15244 111177475 111178011 536 0
RARA MCF7GSE15244 111385739 111386815 1076 0
RARA MCF7GSE15244 111587582 111588422 840 0
RNAII Tamoxifen-MCF7GSE14664 111531546 111531582 36 0
Rb SenescentGSE19898 111184143 111184476 333 0
Rb shRbQuiescentGSE19898 111292502 111292769 267 0
TAF HelaGSE8489 111631571 111632276 705 0
TFAP2C MCF7GSE21234 111255356 111255720 364 0
TFAP2C MCF7GSE21234 111300260 111300937 677 0
TFAP2C MCF7GSE21234 111386285 111386651 366 0
hScc1 BcellGSE12603 111157715 111158020 305 0
hScc1 BcellGSE12603 111162896 111163347 451 0
hScc1 BcellGSE12603 111168931 111169601 670 0
hScc1 BcellGSE12603 111179576 111179814 238 0
hScc1 BcellGSE12603 111519747 111520120 373 0
hScc1 BcellGSE12603 111633211 111634066 855 0
hScc1 CdLSGSE12603 111157646 111158432 786 0
hScc1 CdLSGSE12603 111162748 111163571 823 0
hScc1 CdLSGSE12603 111168864 111169438 574 0
hScc1 CdLSGSE12603 111179576 111179814 238 0
hScc1 CdLSGSE12603 111282404 111282982 578 0
hScc1 CdLSGSE12603 111507703 111508250 547 0
hScc1 CdLSGSE12603 111632243 111634415 2172 0
hScc1 G2GSE9613 111157646 111158468 822 0
hScc1 G2GSE9613 111162601 111164015 1414 0
hScc1 G2GSE9613 111168791 111169601 810 0
hScc1 G2GSE9613 111179576 111179814 238 0
hScc1 G2GSE9613 111190373 111190788 415 0
hScc1 G2GSE9613 111281980 111283446 1466 0
hScc1 G2GSE9613 111632243 111633845 1602 0
p130 SenescentGSE19898 111609973 111610205 232 0
p130 shRbSenescentGSE19898 111184133 111184573 440 0
p63 keratinocytesGSE17611 111380537 111381561 1024 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
24501 EST chr7 111042544 111054056 11512 mRNA DOCK4 chr7 110992655 111106093 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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