AutismKB 2.0

Annotation Detail for SLK


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Basic Information Top
Gene Symbol:SLK ( KIAA0204,LOSK,MGC133067,STK2,bA16H23.1,se20-9 )
Gene Full Name: STE20-like kinase
Band: 10q24.33-q25.1
Quick LinksEntrez ID:9748; OMIM: NA; Uniprot ID:SLK_HUMAN; ENSEMBL ID: ENSG00000065613; HGNC ID: 11088
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
181Phosphothreonine.
189Phosphoserine.
330Phosphoserine.
340Phosphoserine.
341Phosphoserine.
344Phosphoserine.
347Phosphoserine.
348Phosphoserine.
354Phosphoserine.
370Phosphoserine.
546Phosphoserine.
565Phosphoserine.
569Phosphothreonine.
571Phosphoserine.
655Phosphoserine.
728Phosphoserine.
755Phosphothreonine.
772Phosphoserine.
777Phosphoserine.
779Phosphoserine.
814Phosphothreonine.
818Phosphoserine.
1097Phosphothreonine.
1229Phosphoserine.
1235Phosphoserine.
Location(AA) Modifications Resource
189Phosphoserine.Swiss-Prot 53.0
340Phosphoserine.Swiss-Prot 53.0
341Phosphoserine.Swiss-Prot 53.0
344Phosphoserine.Swiss-Prot 53.0
347Phosphoserine.Swiss-Prot 53.0
348Phosphoserine.Swiss-Prot 53.0
571PhosphoserinePhospho.ELM 6.0
779Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
67Phosphothreonine(CK2)HMM predict
76SulfotyrosineHMM predict
76Phosphotyrosine(INSR)HMM predict
189PhosphoserineHMM predict
340Phosphoserine(CK2)HMM predict
341Phosphoserine(PKA)HMM predict
341Phosphoserine(CK1)HMM predict
344Phosphoserine(IKK)HMM predict
347Phosphoserine(CK2)HMM predict
364Phosphoserine(CK2)HMM predict
386Phosphothreonine(PKC)HMM predict
571Phosphoserine(IKK)HMM predict
637Phosphothreonine(CK2)HMM predict
647Phosphoserine(CK2)HMM predict
748N-linkedHMM predict
750Phosphoserine(CK1)HMM predict
754Phosphoserine(IKK)HMM predict
755O-linkedHMM predict
779Phosphoserine(CK1)HMM predict
779Phosphoserine(IKK)HMM predict
791Phosphothreonine(PKC)HMM predict
806Phosphoserine(IKK)HMM predict
814O-linkedHMM predict
818Phosphoserine(CK1)HMM predict
818Phosphoserine(CK2)HMM predict
869Phosphoserine(CK1)HMM predict
888Phosphothreonine(PKC)HMM predict
955Phosphoserine(ATM)HMM predict
1093N-linkedHMM predict
1172Phosphoserine(CK1)HMM predict
1172Phosphoserine(ATM)HMM predict
1188Phosphothreonine(PKC)HMM predict
1214N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014720
  • Location:chr10 105717459-105777331
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 105698439 105698618 179 18931
PHF8 293TGSE20725 105716186 105717603 1417 565
PHF8 HeLaGSE20725 105716333 105717617 1284 485
PHF8 Hs68minusFBSGSE20725 105716188 105717352 1164 690
TAF HelaGSE8489 105716434 105716653 219 916
TAF k562GSE8489 105716434 105716732 298 877
TFAP2C MCF7GSE21234 105698121 105698770 649 19014
p63 keratinocytesGSE17611 105708516 105709346 830 8529
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 105777972 105778184 212 747
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER Fulvestrant-MCF7GSE14664 105731923 105731958 35 0
H3K4me3 colorectalcancer 105717419 105718479 1060 0
H3ac HepG2E 105717419 105718004 585 0
H3ac HepG2E 105719016 105719965 949 0
Nanog hESGSE18292 105749770 105749942 172 0
Oct1 H2O2-HelaGSE14283 105731924 105731958 34 0
Oct1 HelaGSE14283 105731923 105731962 39 0
Oct1 HelaGSE14283 105776822 105776861 39 0
RNAII Tamoxifen-MCF7GSE14664 105731922 105731957 35 0
Rb QuiescentGSE19898 105717477 105717663 186 0
Rb QuiescentGSE19898 105717949 105718157 208 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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