AutismKB 2.0

Annotation Detail for TOX


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Basic Information Top
Gene Symbol:TOX ( KIAA0808,TOX1 )
Gene Full Name: thymocyte selection-associated high mobility group box
Band: 8q12.1
Quick LinksEntrez ID:9760; OMIM: 606863; Uniprot ID:TOX_HUMAN; ENSEMBL ID: ENSG00000198846; HGNC ID: 18988
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
256Nuclear localization signal (Potential).
Location(AA) Modifications Resource
Location(AA) Modification Resource
41Phosphotyrosine(SRC)HMM predict
41PhosphotyrosineHMM predict
41Phosphotyrosine(INSR)HMM predict
41Phosphotyrosine(Syk)HMM predict
51Phosphotyrosine(Syk)HMM predict
57Phosphoserine(IKK)HMM predict
74Phosphothreonine(MAPK)HMM predict
74Phosphothreonine(CDK)HMM predict
77O-linkedHMM predict
149Phosphotyrosine(Abl)HMM predict
204Phosphoserine(CDK)HMM predict
204Phosphoserine(CDC2)HMM predict
206Phosphoserine(CDC2)HMM predict
206O-linkedHMM predict
206Phosphoserine(ATM)HMM predict
214Phosphothreonine(MAPK)HMM predict
214O-linkedHMM predict
214O-linkedHMM predict
214O-linkedHMM predict
216Phosphoserine(ATM)HMM predict
216O-linkedHMM predict
216Phosphoserine(IKK)HMM predict
216Phosphoserine(CDC2)HMM predict
220Phosphoserine(ATM)HMM predict
220Phosphoserine(CK1)HMM predict
249Phosphothreonine(MAPK)HMM predict
249PhosphothreonineHMM predict
249Phosphothreonine(CDK)HMM predict
249Phosphothreonine(CDC2)HMM predict
285N-linkedHMM predict
310Phosphotyrosine(EGFR)HMM predict
334O-linkedHMM predict
363Phosphoserine(ATM)HMM predict
409Phosphoserine(IKK)HMM predict
416Phosphoserine(CDC2)HMM predict
416Phosphoserine(CDK)HMM predict
416O-linkedHMM predict
424O-linkedHMM predict
459Phosphoserine(MAPK)HMM predict
459Phosphoserine(CDK)HMM predict
477N-linkedHMM predict
479O-linkedHMM predict
481O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014729
  • Location:chr8 59880530-60194320
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 60194802 60194950 148 556
CTCF CD4SISSRdata 60194802 60194950 148 556
CTCF G2GSE9613 60194439 60195150 711 474
PHF8 HeLaGSE20725 60194290 60195353 1063 501
hScc1 BcellGSE12603 60194520 60195150 630 515
p130 QuiescentGSE19898 60194635 60194888 253 441
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 59874157 59878310 4153 4297
Gata2 K562GSE18868 59876268 59877160 892 3817
Rb shRbQuiescentGSE19898 59864336 59864510 174 16108
STAT1 HeLaGSE12783 59875719 59877428 1709 3957
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 59916940 59917887 947 0
CBP T30-glioblastomaGSE21026 60163493 60164322 829 0
CTCF CD4GSE12889 59882969 59883487 518 0
CTCF CD4GSE12889 60096443 60096579 136 0
CTCF CD4SISSRdata 59882969 59883487 518 0
CTCF CD4SISSRdata 60096443 60096579 136 0
CTCF G2GSE9613 59882936 59883539 603 0
CTCF G2GSE9613 60111213 60111356 143 0
FOXA1 DLD1GSE12801 60105227 60106220 993 0
Fos K562GSE19551 59917100 59917607 507 0
FoxA1 MCF7MACSdata 59886160 59886370 210 0
FoxA1 MCF7MACSdata 60064938 60065147 209 0
GABP HelaGSE8489 60064923 60065135 212 0
H3K4me3 colorectalcancer 60192037 60193020 983 0
Myc K562GSE19551 60066951 60067235 284 0
Myc hESGSE17917 60130227 60130477 250 0
NRSF pAbJurkat 60115852 60116152 300 0
Nanog ESGSE20650 60154174 60154761 587 0
Oct1 H2O2-HelaGSE14283 60084407 60084434 27 0
Oct1 H2O2-HelaGSE14283 60115922 60115950 28 0
Oct1 HelaGSE14283 60006420 60006457 37 0
Oct1 HelaGSE14283 60084400 60084432 32 0
Oct1 HelaGSE14283 60123833 60123892 59 0
Oct1 HelaGSE14283 60172380 60172433 53 0
P300 T30-glioblastomaGSE21026 59916793 59917974 1181 0
P300 T30-glioblastomaGSE21026 60163363 60164410 1047 0
RARG MCF7GSE15244 59897539 59897834 295 0
Stat6 IL-4-hr4GSE17850 60022764 60023703 939 0
TFAP2C MCF7GSE21234 59933394 59933905 511 0
hScc1 BcellGSE12603 59882870 59883574 704 0
hScc1 BcellGSE12603 60192322 60192652 330 0
hScc1 BcellGSE12603 60193055 60193944 889 0
hScc1 CdLSGSE12603 59882870 59883574 704 0
hScc1 G2GSE9613 59882911 59883649 738 0
p63 keratinocytesGSE17611 60010825 60011703 878 0
p63 keratinocytesGSE17611 60028244 60029028 784 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25480 EST TOX chr8 59881302 59881957 655 mRNA TOX chr8 59880530 60194321Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018