AutismKB 2.0

Annotation Detail for EIF4A3


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Basic Information Top
Gene Symbol:EIF4A3 ( DDX48,DKFZp686O16189,KIAA0111,MGC10862,NMP265,NUK34,eIF4AIII )
Gene Full Name: eukaryotic translation initiation factor 4A3
Band: 17q25.3
Quick LinksEntrez ID:9775; OMIM: 608546; Uniprot ID:IF4A3_HUMAN; ENSEMBL ID: ENSG00000141543; HGNC ID: 18683
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
10Phosphoserine.
12Phosphoserine.
60N6-acetyllysine.
66Q motif.
163Phosphothreonine.
190DEAD box.
296N6-acetyllysine.
321N6-acetyllysine.
Location(AA) Modifications Resource
2N-acetylalanine.Swiss-Prot 53.0
Location(AA) Modification Resource
31Phosphoserine(CK2)HMM predict
84Phosphoserine(IKK)HMM predict
86O-linkedHMM predict
89O-linkedHMM predict
132Phosphotyrosine(INSR)HMM predict
163Phosphothreonine(CDC2)HMM predict
163Phosphothreonine(MAPK)HMM predict
175Phosphoserine(PKG)HMM predict
202Phosphotyrosine(SRC)HMM predict
301N-linkedHMM predict
395Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014740
  • Location:chr17 75723613-75735532
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 75735153 75736124 971 106
Nanog hESGSE18292 75748225 75748422 197 12791
Oct1 HelaGSE14283 75737934 75737996 62 2433
RARG MCF7GSE15244 75748475 75748720 245 13065
STAT1 HeLaGSE12782 75739851 75741858 2007 5322
STAT1 HeLaGSE12783 75739885 75741824 1939 5322
Sox2 hESGSE18292 75748231 75748423 192 12795
TFAP2C MCF7GSE21234 75735477 75735887 410 150
TFAP2C MCF7GSE21234 75743984 75744473 489 8696
p130 SenescentGSE19898 75735560 75735984 424 240
p130 shRbQuiescentGSE19898 75739728 75740167 439 4415
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 75722028 75722435 407 1382
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me2 HCT116GSE10453 75733992 75734698 706 0
H3K4me3 colorectalcancer 75734098 75734656 558 0
H3ac HepG2E 75732391 75733651 1260 0
H3ac HepG2E 75733992 75734865 873 0
Rb QuiescentGSE19898 75734657 75734980 323 0
Rb SenescentGSE19898 75735216 75735400 184 0
Rb shRbQuiescentGSE19898 75734709 75735027 318 0
TAF HelaGSE8489 75733992 75734698 706 0
TAF k562GSE8489 75733992 75734865 873 0
hScc1 BcellGSE12603 75734729 75735359 630 0
p130 QuiescentGSE19898 75734810 75734975 165 0
p130 SenescentGSE19898 75734550 75735039 489 0
p130 shRbSenescentGSE19898 75734619 75735100 481 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018