AutismKB 2.0

Annotation Detail for ARHGEF11


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Basic Information Top
Gene Symbol:ARHGEF11 ( DKFZp667F1223,GTRAP48,KIAA0380,PDZ-RHOGEF )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 11
Band: 1q23.1
Quick LinksEntrez ID:9826; OMIM: 605708; Uniprot ID:ARHGB_HUMAN; ENSEMBL ID: ENSG00000132694; HGNC ID: 14580
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
245Phosphoserine.
251Phosphoserine.
254Phosphothreonine.
255Phosphoserine.
663Phosphoserine.
668Phosphothreonine.
672Phosphothreonine.
1155Phosphoserine.
1295Phosphoserine.
1300Phosphoserine.
1457Phosphoserine.
1458Phosphoserine.
1462Phosphothreonine.
1475Phosphothreonine.
1480Phosphoserine.
1489Phosphoserine.
1491Phosphoserine.
Location(AA) Modifications Resource
251PhosphoserinePhospho.ELM 6.0
663Phosphoserine.Swiss-Prot 53.0
663PhosphoserinePhospho.ELM 6.0
668Phosphothreonine.Swiss-Prot 53.0
668PhosphothreoninePhospho.ELM 6.0
1155Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
14Phosphoserine(CK1)HMM predict
16Phosphoserine(CK1)HMM predict
17Phosphoserine(CK1)HMM predict
27PhosphoserineHMM predict
35PhosphoserineHMM predict
35Phosphoserine(PKB)HMM predict
35Phosphoserine(CK2)HMM predict
93N-linkedHMM predict
99N-linkedHMM predict
123Phosphoserine(CDC2)HMM predict
123Phosphoserine(ATM)HMM predict
126Phosphoserine(IKK)HMM predict
137Phosphoserine(CDC2)HMM predict
146O-linkedHMM predict
150Phosphoserine(CDC2)HMM predict
150O-linkedHMM predict
150Phosphoserine(ATM)HMM predict
150Phosphoserine(CDK)HMM predict
213Phosphoserine(PKG)HMM predict
216Phosphoserine(ATM)HMM predict
216Phosphoserine(CK1)HMM predict
232Phosphoserine(PKB)HMM predict
232Phosphoserine(IKK)HMM predict
251Phosphoserine(CDC2)HMM predict
255Phosphoserine(CDC2)HMM predict
255PhosphoserineHMM predict
271Phosphoserine(PKA)HMM predict
271Phosphoserine(CAMK2)HMM predict
298SulfotyrosineHMM predict
298Phosphotyrosine(Syk)HMM predict
298Phosphotyrosine(INSR)HMM predict
302Phosphotyrosine(INSR)HMM predict
305N-linkedHMM predict
333Phosphoserine(ATM)HMM predict
424Phosphothreonine(PKA)HMM predict
479Phosphotyrosine(INSR)HMM predict
521Phosphoserine(CK1)HMM predict
545Phosphoserine(IKK)HMM predict
556Phosphoserine(CDC2)HMM predict
578SulfotyrosineHMM predict
578Phosphotyrosine(SRC)HMM predict
578Phosphotyrosine(Syk)HMM predict
590Phosphothreonine(PKC)HMM predict
592Phosphoserine(CK2)HMM predict
603Phosphoserine(CK1)HMM predict
605Phosphoserine(CK1)HMM predict
624Phosphoserine(PKG)HMM predict
635Phosphoserine(PKB)HMM predict
651O-linkedHMM predict
654Phosphoserine(CK1)HMM predict
656O-linkedHMM predict
657Phosphoserine(CK1)HMM predict
657Phosphoserine(IKK)HMM predict
658Phosphoserine(CK1)HMM predict
666N-linkedHMM predict
729Phosphothreonine(PKC)HMM predict
1023Phosphoserine(CDC2)HMM predict
1057Phosphotyrosine(SRC)HMM predict
1057Phosphotyrosine(Syk)HMM predict
1080N-linkedHMM predict
1108Phosphothreonine(MAPK)HMM predict
1155Phosphoserine(CK2)HMM predict
1235Phosphothreonine(MAPK)HMM predict
1237Phosphothreonine(MAPK)HMM predict
1242Phosphoserine(CK1)HMM predict
1242O-linkedHMM predict
1252O-linkedHMM predict
1312Phosphoserine(CK1)HMM predict
1313Phosphoserine(CK1)HMM predict
1313O-linkedHMM predict
1343Phosphoserine(IKK)HMM predict
1362Phosphotyrosine(Jak)HMM predict
1367O-linkedHMM predict
1377Phosphoserine(IKK)HMM predict
1382PhosphoserineHMM predict
1382Phosphoserine(IKK)HMM predict
1382O-linkedHMM predict
1382Phosphoserine(ATM)HMM predict
1388Phosphoserine(IKK)HMM predict
1411Phosphoserine(PKG)HMM predict
1413O-linkedHMM predict
1413Phosphoserine(ATM)HMM predict
1458O-linkedHMM predict
1462PhosphothreonineHMM predict
1480Phosphoserine(CDC2)HMM predict
1480Phosphoserine(MAPK)HMM predict
1480Phosphoserine(CDK)HMM predict
1480Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014784
  • Location:chr1 155171256-155281785
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
KLF4 hESGSE17917 155282237 155282613 376 640
Oct1 HelaGSE14283 155284953 155284989 36 3186
Oct1 HelaGSE14283 155298758 155298800 42 16994
PHF8 293TGSE20725 155281659 155282985 1326 537
PHF8 Hs68plusFBSGSE20725 155281370 155282991 1621 395
RNAII Tamoxifen-MCF7GSE14664 155290757 155290794 37 8990
Rb QuiescentGSE19898 155282148 155282435 287 506
TAF k562GSE8489 155283025 155283166 141 1310
hScc1 BcellGSE12603 155282131 155282751 620 656
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 155206549 155206711 162 0
CTCF CD4SISSRdata 155206549 155206711 162 0
CTCF G2GSE9613 155174135 155174283 148 0
CTCF G2GSE9613 155174878 155175258 380 0
CTCF G2GSE9613 155184334 155184976 642 0
CTCF G2GSE9613 155185630 155185851 221 0
CTCF G2GSE9613 155197952 155198822 870 0
ER E2-MCF7GSE14664 155265910 155265944 34 0
FoxA1 MCF7MACSdata 155261502 155261733 231 0
Gata2 K562GSE18868 155194511 155195324 813 0
H3K4me3 colorectalcancer 155280198 155281690 1492 0
H3ac HepG2E 155279675 155281801 2126 0
Nanog hESGSE18292 155211250 155212030 780 0
Oct1 H2O2-HelaGSE14283 155262786 155262813 27 0
Oct1 H2O2-HelaGSE14283 155264751 155264777 26 0
Oct1 HelaGSE14283 155225260 155225292 32 0
Oct1 HelaGSE14283 155264751 155264786 35 0
Oct1 HelaGSE14283 155280728 155280762 34 0
RARA MCF7GSE15244 155194108 155195331 1223 0
RNAII Tamoxifen-MCF7GSE14664 155238743 155238843 100 0
Rb GrowingGSE19898 155187893 155188081 188 0
Sox2 hESGSE18292 155211554 155211777 223 0
TAF HelaGSE8489 155232262 155232409 147 0
TAF k562GSE8489 155280813 155281837 1024 0
hScc1 BcellGSE12603 155174395 155175462 1067 0
hScc1 BcellGSE12603 155177935 155178500 565 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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