AutismKB 2.0

Annotation Detail for MELK


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Basic Information Top
Gene Symbol:MELK ( HPK38,KIAA0175 )
Gene Full Name: maternal embryonic leucine zipper kinase
Band: 9p13.2
Quick LinksEntrez ID:9833; OMIM: 607025; Uniprot ID:MELK_HUMAN; ENSEMBL ID: ENSG00000165304; HGNC ID: 16870
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
335Phosphoserine.
356Phosphoserine.
431Phosphoserine.
446Phosphothreonine.
460Phosphothreonine.
478Phosphothreonine.
494Phosphothreonine.
498Phosphoserine.
505Phosphoserine.
518Phosphothreonine.
529Phosphoserine.
Location(AA) Modifications Resource
167Phosphothreonine (LKB1)Phospho.ELM 6.0
478Phosphothreonine (Probable).Swiss-Prot 53.0
478PhosphothreoninePhospho.ELM 6.0
505Phosphoserine.Swiss-Prot 53.0
505PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
105Phosphoserine(CK1)HMM predict
105Phosphoserine(CK2)HMM predict
174Phosphotyrosine(INSR)HMM predict
387O-linkedHMM predict
387Phosphothreonine(MAPK)HMM predict
446Phosphothreonine(CDC2)HMM predict
446Phosphothreonine(MAPK)HMM predict
464Phosphotyrosine(INSR)HMM predict
464Phosphotyrosine(Abl)HMM predict
466Phosphothreonine(CDK)HMM predict
466Phosphothreonine(CDK)HMM predict
485N-linkedHMM predict
498Phosphoserine(CDC2)HMM predict
518Phosphothreonine(CDC2)HMM predict
518Phosphothreonine(MAPK)HMM predict
549Phosphoserine(PKG)HMM predict
562N-linkedHMM predict
641LeucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014791
  • Location:chr9 36562904-36667677
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 36545859 36546109 250 16921
CTCF CD4SISSRdata 36545859 36546109 250 16921
ER E2-MCF7GSE14664 36557317 36557351 34 5571
ER Fulvestrant-MCF7GSE14664 36557315 36557350 35 5572
Nanog hESGSE18292 36550844 36551022 178 11972
Oct1 HelaGSE14283 36551618 36551658 40 11267
Oct1 HelaGSE14283 36557311 36557345 34 5577
Oct1 HelaGSE14283 36561510 36561542 32 1379
PHF8 293TGSE20725 36562318 36563458 1140 17
PHF8 Hs68minusFBSGSE20725 36562187 36563158 971 232
Rb GrowingGSE19898 36545952 36546073 121 16892
Rb GrowingGSE19898 36562781 36562939 158 45
Rb QuiescentGSE19898 36562770 36562963 193 38
STAT1 HeLaGSE12782 36549826 36551539 1713 12222
STAT1 HeLaGSE12783 36549827 36551472 1645 12255
VDR GM10861-stimGSE22484 36545412 36546611 1199 16893
hScc1 BcellGSE12603 36545922 36546136 214 16876
hScc1 CdLSGSE12603 36545922 36546136 214 16876
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 36610940 36611594 654 0
CTCF CD4GSE12889 36587475 36587731 256 0
CTCF CD4SISSRdata 36587475 36587731 256 0
FoxA1 MCF7MACSdata 36627583 36627788 205 0
H3K4me3 colorectalcancer 36563246 36563462 216 0
H3ac HepG2E 36563246 36563462 216 0
H3ac HepG2E 36565388 36565922 534 0
LIN9 G0GSE7516 36562661 36563462 801 0
LIN9 SGSE7516 36562661 36563462 801 0
Oct1 H2O2-HelaGSE14283 36580225 36580260 35 0
Oct1 HelaGSE14283 36568185 36568221 36 0
Oct1 HelaGSE14283 36570386 36570422 36 0
Oct1 HelaGSE14283 36580221 36580305 84 0
Oct1 HelaGSE14283 36633201 36633249 48 0
Oct1 HelaGSE14283 36657514 36657549 35 0
PHF8 HeLaGSE20725 36562176 36563911 1735 0
Rb shRbQuiescentGSE19898 36562815 36563056 241 0
TAF k562GSE8489 36563246 36563462 216 0
TAF k562GSE8489 36566219 36566498 279 0
hScc1 BcellGSE12603 36627910 36628173 263 0
hScc1 CdLSGSE12603 36627580 36628245 665 0
p130 QuiescentGSE19898 36562560 36563349 789 0
p130 SenescentGSE19898 36562375 36563532 1157 0
p130 shRbQuiescentGSE19898 36562476 36563384 908 0
p130 shRbSenescentGSE19898 36562454 36563411 957 0
p130 shRbSenescentGSE19898 36565589 36566027 438 0
p130 G0GSE7516 36562661 36563426 765 0
p130 SGSE7516 36562700 36563462 762 0
p63 keratinocytesGSE17611 36591410 36592069 659 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-21 hsa-mir-21 17 21274750
hsa-miR-21* hsa-mir-21 17 21274750
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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