AutismKB 2.0

Annotation Detail for RUSC2


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Basic Information Top
Gene Symbol:RUSC2 ( Iporin,KIAA0375 )
Gene Full Name: RUN and SH3 domain containing 2
Band: 9p13.3
Quick LinksEntrez ID:9853; OMIM: 611053; Uniprot ID:RUSC2_HUMAN; ENSEMBL ID: ENSG00000198853; HGNC ID: 23625
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
513Phosphoserine (By similarity).
536Phosphoserine.
656Phosphoserine.
1368Phosphoserine.
1380Phosphoserine.
Location(AA) Modifications Resource
513Phosphoserine (By similarity).Swiss-Prot 53.0
536Phosphoserine.Swiss-Prot 53.0
536PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
161Phosphothreonine(PKC)HMM predict
190S-palmitoylHMM predict
191S-palmitoylHMM predict
211O-linkedHMM predict
243O-linkedHMM predict
256O-linkedHMM predict
256Phosphoserine(CK2)HMM predict
257Phosphoserine(ATM)HMM predict
257Phosphoserine(CK1)HMM predict
259Phosphoserine(CK2)HMM predict
276Phosphoserine(CK1)HMM predict
305Phosphoserine(IKK)HMM predict
349Phosphotyrosine(INSR)HMM predict
409Phosphoserine(CDC2)HMM predict
411Phosphoserine(IKK)HMM predict
411Phosphoserine(MAPK)HMM predict
411Phosphoserine(CDC2)HMM predict
416Phosphoserine(IKK)HMM predict
428O-linkedHMM predict
440Phosphoserine(ATM)HMM predict
440O-linkedHMM predict
462Phosphoserine(CK1)HMM predict
463Phosphoserine(CK1)HMM predict
465O-linkedHMM predict
483N-linkedHMM predict
485Phosphoserine(CDC2)HMM predict
488N-linkedHMM predict
498Phosphoserine(PKB)HMM predict
499Phosphotyrosine(Jak)HMM predict
525Phosphoserine(PKG)HMM predict
536Phosphoserine(CDC2)HMM predict
536Phosphoserine(CDK)HMM predict
542Phosphothreonine(PKA)HMM predict
543Phosphoserine(PKA)HMM predict
554Phosphothreonine(PKC)HMM predict
557O-linkedHMM predict
559Phosphoserine(CDK)HMM predict
614Phosphoserine(ATM)HMM predict
614O-linkedHMM predict
628O-linkedHMM predict
656Phosphoserine(IKK)HMM predict
656Phosphoserine(CDC2)HMM predict
717Phosphoserine(ATM)HMM predict
721Phosphoserine(IKK)HMM predict
742O-linkedHMM predict
742Phosphoserine(IKK)HMM predict
747O-linkedHMM predict
753O-linkedHMM predict
754Phosphothreonine(MAPK)HMM predict
760MethylarginineHMM predict
771Phosphothreonine(PKC)HMM predict
772O-linkedHMM predict
772O-linkedHMM predict
775O-linkedHMM predict
775Phosphoserine(CDC2)HMM predict
795O-linkedHMM predict
795Phosphoserine(IKK)HMM predict
798O-linkedHMM predict
799O-linkedHMM predict
800Phosphoserine(IKK)HMM predict
802Phosphoserine(MAPK)HMM predict
802Phosphoserine(ATM)HMM predict
830Phosphoserine(ATM)HMM predict
869Phosphoserine(PKG)HMM predict
872MethylarginineHMM predict
978Phosphoserine(CDC2)HMM predict
1025N-linkedHMM predict
1031N-linkedHMM predict
1281Phosphotyrosine(Jak)HMM predict
1296Phosphoserine(PKB)HMM predict
1296Phosphoserine(IKK)HMM predict
1297N-linkedHMM predict
1299Phosphoserine(CDC2)HMM predict
1368Phosphoserine(CDC2)HMM predict
1441Phosphoserine(MAPK)HMM predict
1441Phosphoserine(IKK)HMM predict
1502O-linkedHMM predict
1504Phosphothreonine(MAPK)HMM predict
1504O-linkedHMM predict
1506Phosphothreonine(MAPK)HMM predict
1506O-linkedHMM predict
1506O-linkedHMM predict
1508Phosphoserine(CDC2)HMM predict
1508O-linkedHMM predict
1508Phosphoserine(CDK)HMM predict
1510O-linkedHMM predict
1510Phosphothreonine(CDK)HMM predict
1510O-linkedHMM predict
1510Phosphothreonine(MAPK)HMM predict
1511ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014806
  • Location:chr9 35480123-35551888
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 35467361 35467522 161 12682
CTCF CD4SISSRdata 35467361 35467522 161 12682
ER Fulvestrant-MCF7GSE14664 35464216 35464251 35 15890
Rb GrowingGSE19898 35479742 35480018 276 244
Rb QuiescentGSE19898 35479807 35480074 267 183
Rb SenescentGSE19898 35479700 35480132 432 208
Rb shRbQuiescentGSE19898 35479827 35480032 205 194
Rb shRbSenescenceGSE19898 35479672 35480061 389 257
TFAP2C MCF7GSE21234 35479271 35479857 586 560
USF2 HepG2E 35471575 35471815 240 8429
VDR GM10855-stimGSE22484 35466818 35467783 965 12823
hScc1 BcellGSE12603 35467172 35467554 382 12761
hScc1 BcellGSE12603 35471575 35471779 204 8447
hScc1 CdLSGSE12603 35466857 35467554 697 12918
hScc1 CdLSGSE12603 35471575 35471887 312 8393
p130 QuiescentGSE19898 35479830 35479945 115 236
p130 SenescentGSE19898 35479834 35480047 213 183
p130 shRbSenescentGSE19898 35467292 35467491 199 12732
p130 shRbSenescentGSE19898 35479392 35480254 862 301
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 35500356 35501916 1560 0
CBP T30-glioblastomaGSE21026 35507691 35509813 2122 0
CTCF CD4GSE12889 35544061 35544320 259 0
CTCF CD4SISSRdata 35544061 35544320 259 0
CTCF JurkatGSE12889 35544065 35544233 168 0
ER MCF7GSE19013 35507714 35508582 868 0
ER MCF7GSE19013 35510079 35510487 408 0
FOXA1 MCF7GSE15244 35508061 35509432 1371 0
FoxA1 MCF7MACSdata 35508145 35508458 313 0
H3K4me2 HCT116GSE10453 35480915 35481570 655 0
H3ac HepG2E 35480845 35481640 795 0
Myc hESGSE17917 35479951 35480325 374 0
P300 T30-glioblastomaGSE21026 35500128 35501900 1772 0
P300 T30-glioblastomaGSE21026 35507617 35510109 2492 0
RARA MCF7GSE15244 35508061 35509432 1371 0
Rb GrowingGSE19898 35528675 35528900 225 0
Rb GrowingGSE19898 35543958 35544297 339 0
Rb QuiescentGSE19898 35543902 35544201 299 0
Rb SenescentGSE19898 35543786 35544330 544 0
TAF HelaGSE8489 35480845 35481532 687 0
TAF k562GSE8489 35480880 35481640 760 0
TAFII hESGSE17917 35543841 35544263 422 0
TFAP2C MCF7GSE21234 35508022 35508612 590 0
hScc1 BcellGSE12603 35480342 35480880 538 0
hScc1 BcellGSE12603 35538281 35538664 383 0
hScc1 BcellGSE12603 35543836 35544375 539 0
hScc1 BcellGSE12603 35544941 35545342 401 0
hScc1 CdLSGSE12603 35543806 35544375 569 0
p130 QuiescentGSE19898 35528510 35528935 425 0
p130 SenescentGSE19898 35528635 35528955 320 0
p130 SenescentGSE19898 35543871 35544232 361 0
p130 shRbQuiescentGSE19898 35528036 35529119 1083 0
p130 shRbSenescentGSE19898 35528551 35529131 580 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
26374 mRNA RUSC2 chr9 35480123 35551889 63 EST chr9 35551826 35552516Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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