AutismKB 2.0

Annotation Detail for NUAK1


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Basic Information Top
Gene Symbol:NUAK1 ( ARK5,KIAA0537 )
Gene Full Name: NUAK family, SNF1-like kinase, 1
Band: 12q23.3
Quick LinksEntrez ID:9891; OMIM: 608130; Uniprot ID:NUAK1_HUMAN; ENSEMBL ID: ENSG00000074590; HGNC ID: 14311
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
22Phosphoserine.
211Phosphothreonine.
215Phosphoserine (By similarity).
371Phosphoserine (By similarity).
380Phosphoserine (By similarity).
388Phosphoserine.
444Phosphoserine.
445Phosphoserine.
455Phosphoserine.
600Phosphoserine; by PKB/AKT1.
Location(AA) Modifications Resource
211Phosphothreonine.Swiss-Prot 53.0
211Phosphothreonine (LKB1)Phospho.ELM 6.0
215Phosphoserine (By similarity).Swiss-Prot 53.0
371Phosphoserine (By similarity).Swiss-Prot 53.0
380Phosphoserine (By similarity).Swiss-Prot 53.0
600Phosphoserine (by PKB/AKT1).Swiss-Prot 53.0
600Phosphoserine (PKB
Location(AA) Modification Resource
73Phosphothreonine(PKA)HMM predict
73Phosphothreonine(PKC)HMM predict
141Phosphotyrosine(INSR)HMM predict
143Phosphotyrosine(INSR)HMM predict
151PhosphoserineHMM predict
151Phosphoserine(PKA)HMM predict
151Phosphoserine(PKC)HMM predict
151Phosphoserine(PKG)HMM predict
151Phosphoserine(CAMK2)HMM predict
211PhosphothreonineHMM predict
218Phosphotyrosine(Abl)HMM predict
218Phosphotyrosine(INSR)HMM predict
220Phosphoserine(CDK)HMM predict
220Phosphoserine(CDC2)HMM predict
229Phosphotyrosine(Abl)HMM predict
266Phosphoserine(PKG)HMM predict
270Phosphotyrosine(SRC)HMM predict
270Phosphotyrosine(INSR)HMM predict
274PhosphothreonineHMM predict
296Phosphothreonine(PKC)HMM predict
367PhosphoserineHMM predict
367Phosphoserine(CAMK2)HMM predict
367Phosphoserine(PKG)HMM predict
388Phosphoserine(CDK)HMM predict
388Phosphoserine(CDC2)HMM predict
390Phosphoserine(IKK)HMM predict
390Phosphoserine(CK1)HMM predict
407Phosphoserine(CK1)HMM predict
445Phosphoserine(CDK)HMM predict
445Phosphoserine(MAPK)HMM predict
445Phosphoserine(CDC2)HMM predict
445Phosphoserine(ATM)HMM predict
455Phosphoserine(CDC2)HMM predict
479Phosphotyrosine(SRC)HMM predict
479Phosphotyrosine(INSR)HMM predict
480Phosphoserine(CK2)HMM predict
481Phosphoserine(ATM)HMM predict
481Phosphoserine(CDC2)HMM predict
485Phosphoserine(CK1)HMM predict
487Phosphoserine(CK1)HMM predict
487PhosphoserineHMM predict
503Phosphoserine(CDK)HMM predict
503Phosphoserine(CDC2)HMM predict
503O-linkedHMM predict
505O-linkedHMM predict
505Phosphoserine(ATM)HMM predict
552Phosphoserine(CK1)HMM predict
552O-linkedHMM predict
566Phosphoserine(IKK)HMM predict
570Phosphoserine(IKK)HMM predict
576Phosphoserine(IKK)HMM predict
638Phosphoserine(CK1)HMM predict
654LeucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014840
  • Location:chr12 104981254-105057940
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 105057709 105058634 925 231
CTCF G2GSE9613 105065845 105066097 252 8031
CTCF G2GSE9613 105066745 105067427 682 9146
ER E2-MCF7GSE14664 105068299 105068359 60 10389
FOXA1 MCF7GSE15244 105058462 105058634 172 608
H3ac HepG2E 105057960 105058634 674 357
Oct1 HelaGSE14283 105068269 105068394 125 10391
RARA MCF7GSE15244 105069736 105070155 419 12005
hScc1 G2GSE9613 105065720 105066097 377 7968
hScc1 G2GSE9613 105066745 105067427 682 9146
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 104966786 104967398 612 14163
CTCF G2GSE9613 104976510 104976777 267 4611
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 105001286 105002632 1346 0
CTCF G2GSE9613 104987823 104988277 454 0
CTCF G2GSE9613 105002055 105002554 499 0
CTCF G2GSE9613 105009316 105009678 362 0
CTCF G2GSE9613 105012805 105012944 139 0
CTCF G2GSE9613 105019062 105019207 145 0
CTCF G2GSE9613 105025395 105025763 368 0
CTCF G2GSE9613 105029137 105029437 300 0
CTCF G2GSE9613 105030060 105030353 293 0
CTCF G2GSE9613 105050529 105051336 807 0
CTCF G2GSE9613 105054013 105054576 563 0
CTCF G2GSE9613 105056046 105057125 1079 0
FOXA1 MCF7GSE15244 105014299 105014939 640 0
FOXA1 MCF7GSE15244 105024626 105025836 1210 0
H3ac HepG2E 105043113 105043270 157 0
NFkBII GM12878GSE19485 104990514 104993019 2505 0
NRSF pAbJurkat 104991086 104991337 251 0
NRSF pAbJurkat 105009412 105009678 266 0
NRSF pAbJurkat 105019710 105019954 244 0
Oct1 HelaGSE14283 104984128 104984162 34 0
Oct1 HelaGSE14283 105040151 105040180 29 0
Oct1 HelaGSE14283 105053876 105053904 28 0
Oct1 HelaGSE14283 105053969 105053998 29 0
P300 T30-glioblastomaGSE21026 105001700 105002675 975 0
P300 T30-glioblastomaGSE21026 105008609 105009396 787 0
PHF8 HeLaGSE20725 105056144 105058185 2041 0
RARA MCF7GSE15244 105024342 105025874 1532 0
RARA MCF7GSE15244 105044531 105044886 355 0
RARA MCF7GSE15244 105053154 105055656 2502 0
RARG MCF7GSE15244 105013320 105013858 538 0
RARG MCF7GSE15244 105024480 105026102 1622 0
RARG MCF7GSE15244 105044753 105044886 133 0
RARG MCF7GSE15244 105051188 105051944 756 0
RARG MCF7GSE15244 105053360 105054788 1428 0
Rb GrowingGSE19898 105057446 105057602 156 0
TFAP2C MCF7GSE21234 105024782 105025259 477 0
TFAP2C MCF7GSE21234 105057213 105057835 622 0
hScc1 BcellGSE12603 105054041 105054646 605 0
hScc1 BcellGSE12603 105056094 105056667 573 0
hScc1 CdLSGSE12603 105054041 105054680 639 0
hScc1 G2GSE9613 105029137 105029437 300 0
hScc1 G2GSE9613 105050750 105051393 643 0
hScc1 G2GSE9613 105053543 105054576 1033 0
hScc1 G2GSE9613 105055728 105057864 2136 0
p130 QuiescentGSE19898 105057451 105058119 668 0
p130 SenescentGSE19898 105057737 105057996 259 0
p63 keratinocytesGSE17611 105005892 105006837 945 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-138 hsa-mir-138-2 16 19888451
hsa-miR-138 hsa-mir-138-1 3 19888451
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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