Evidence Details for LZTS1
Basic Information Top
| Gene Symbol: | LZTS1 ( F37,FEZ1 ) |
|---|---|
| Gene Full Name: | leucine zipper, putative tumor suppressor 1 |
| Band: | 8p21.3 |
| Quick Links | Entrez ID:11178; OMIM: 606551; Uniprot ID:LZTS1_HUMAN; ENSEMBL ID: ENSG00000061337; HGNC ID: 13861 |
| Relate to Another Database: | SFARIGene; denovo-db |
Sequences Top>LZTS1|11178|nucleotide
ATGGGCAGCGTCAGTAGCCTCATCTCCGGCCACAGCTTCCACAGCAAGCACTGCCGGGCTTCGCAGTACAAGCTGCGCAAGTCCTCCCACCTCAAGAAGCTCAAC
CGGTATTCCGACGGGCTGCTGAGGTTTGGCTTCTCCCAGGACTCCGGTCACGGCAAGTCCAGCTCCAAAATGGGCAAGAGCGAAGACTTCTTCTACATCAAGGTC
AGCCAGAAAGCCCGGGGCTCCCATCACCCAGATTACACGGCACTGTCCAGCGGGGATTTAGGGGGCCAGGCTGGGGTGGACTTTGACCCGTCCACACCCCCCAAG
CTCATGCCCTTCTCCAATCAGCTAGAAATGGGCTCCGAGAAGGGTGCAGTGAGGCCCACAGCCTTCAAGCCTGTGCTGCCACGGTCAGGAGCCATCCTGCACTCC
TCCCCGGAGAGTGCCAGCCACCAGCTGCACCCCGCCCCTCCAGACAAGCCCAAGGAGCAGGAGCTGAAGCCTGGCCTGTGCTCTGGGGCGCTGTCAGACTCCGGC
CGGAACTCCATGTCCAGCCTGCCCACACACAGCACCAGCAGCAGCTACCAGCTGGACCCGCTGGTCACACCCGTGGGACCCACAAGCCGTTTTGGGGGCTCCGCC
CACAACATCACCCAGGGCATCGTCCTCCAGGACAGCAACATGATGAGCCTGAAGGCTCTGTCCTTCTCCGACGGAGGTAGCAAGCTGGGCCACTCGAACAAGGCA
GACAAGGGCCCCTCGTGTGTCCGCTCCCCCATCTCCACGGACGAGTGCAGCATCCAGGAGCTGGAGCAGAAGCTGTTGGAGAGGGAGGGCGCCCTCCAGAAGCTG
CAGCGCAGCTTTGAGGAGAAGGAGCTTGCCTCCAGCCTGGCCTACGAGGAGCGGCCGCGGCGCTGCAGGGACGAGCTGGAGGGCCCGGAGCCCAAAGGCGGCAAC
AAGCTCAAGCAGGCCTCGCAGAAGAGCCAGCGCGCGCAGCAGGTCCTGCACCTGCAGGTACTGCAGCTTCAGCAGGAGAAGCGGCAGCTCCGGCAGGAGCTCGAG
AGCCTCATGAAGGAGCAGGACCTGCTGGAGACCAAGCTCAGGTCCTACGAGAGGGAGAAGACCAGCTTCGGCCCCGCGCTGGAGGAGACCCAGTGGGAGGTGTGC
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ATGGGCAGCGTCAGTAGCCTCATCTCCGGCCACAGCTTCCACAGCAAGCACTGCCGGGCTTCGCAGTACAAGCTGCGCAAGTCCTCCCACCTCAAGAAGCTCAAC
CGGTATTCCGACGGGCTGCTGAGGTTTGGCTTCTCCCAGGACTCCGGTCACGGCAAGTCCAGCTCCAAAATGGGCAAGAGCGAAGACTTCTTCTACATCAAGGTC
AGCCAGAAAGCCCGGGGCTCCCATCACCCAGATTACACGGCACTGTCCAGCGGGGATTTAGGGGGCCAGGCTGGGGTGGACTTTGACCCGTCCACACCCCCCAAG
CTCATGCCCTTCTCCAATCAGCTAGAAATGGGCTCCGAGAAGGGTGCAGTGAGGCCCACAGCCTTCAAGCCTGTGCTGCCACGGTCAGGAGCCATCCTGCACTCC
TCCCCGGAGAGTGCCAGCCACCAGCTGCACCCCGCCCCTCCAGACAAGCCCAAGGAGCAGGAGCTGAAGCCTGGCCTGTGCTCTGGGGCGCTGTCAGACTCCGGC
CGGAACTCCATGTCCAGCCTGCCCACACACAGCACCAGCAGCAGCTACCAGCTGGACCCGCTGGTCACACCCGTGGGACCCACAAGCCGTTTTGGGGGCTCCGCC
CACAACATCACCCAGGGCATCGTCCTCCAGGACAGCAACATGATGAGCCTGAAGGCTCTGTCCTTCTCCGACGGAGGTAGCAAGCTGGGCCACTCGAACAAGGCA
GACAAGGGCCCCTCGTGTGTCCGCTCCCCCATCTCCACGGACGAGTGCAGCATCCAGGAGCTGGAGCAGAAGCTGTTGGAGAGGGAGGGCGCCCTCCAGAAGCTG
CAGCGCAGCTTTGAGGAGAAGGAGCTTGCCTCCAGCCTGGCCTACGAGGAGCGGCCGCGGCGCTGCAGGGACGAGCTGGAGGGCCCGGAGCCCAAAGGCGGCAAC
AAGCTCAAGCAGGCCTCGCAGAAGAGCCAGCGCGCGCAGCAGGTCCTGCACCTGCAGGTACTGCAGCTTCAGCAGGAGAAGCGGCAGCTCCGGCAGGAGCTCGAG
AGCCTCATGAAGGAGCAGGACCTGCTGGAGACCAAGCTCAGGTCCTACGAGAGGGAGAAGACCAGCTTCGGCCCCGCGCTGGAGGAGACCCAGTGGGAGGTGTGC
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>LZTS1|11178|protein
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPK
LMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSA
HNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN
KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGF
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MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPK
LMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSA
HNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN
KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGF
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Evidence summary TopClick the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
| Evidences | Syndromic Gene | GWAS | CNV | Linkage | Association | Expression | NGS de novo | NGS Mosaic | NGS Other | Low-Scale Gene Studies | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Score (No. of Studies) | No | 0 (1) | 1 (4) | 1 (1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 4 (6) |
Syndromic Autism Gene TopGenome-Wide Association Studies (By Ethnic Group) Top Family Based Association Studies: 1
| Reference | Stage | Platform | #Families | Affecteds | Result | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| #Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ (range) |
||||||
| CAUCASIAN | |||||||||||
| Hussman, 2011_1 | Discovery | Illumina Infinium Human 1 M beadship | 597 | - (-) |  |  | ASD | - - |
- - | ||
Case Control Based Association Studies: 0
| Reference | Stage | Platform | ASD Cases | Normal Controls | Result | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ | #Subjects (% Women) |
Age (range) |
|||||
| No Evidence. | ||||||||||||
CNV Studies Top| Reference | Source | Method | ADI-R | ADOS | Diagnosis | Family | Individual | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Simplex | Multiplex | Control | Affected | Control | Total | ||||||
| Papanikolaou, 2006 | - | FISH | | | autism | - | - | - | - | 1 | - | 1 |
| Gregory, 2009 | USA | aCGH | | | ASD | - | - | - | - | 119 | 54 | 173 |
| Ozgen, 2009 | - | aCGH, SNP microarray | | | ASD | 55 | - | - | - | - | - | - |
| Berkel, 2010 | Canada | SNP microarray | | | ASD | - | - | - | - | 396 | 5023 | 5419 |
Linkage Studies Top| Reference | Source | Method | ADI-R | ADOS | Diagnosis | Family | Individual | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Simplex | Multiplex | Control | Affected | Control | Total | ||||||
| Bailey, 1998 | - | microsatellite-based genomic screen | | | PDD | 99 | - | 99 | - | - | - | - |
Low Scale Association Studies (by Ethnic Group) TopLarge Scale Expression Studies TopNGS de novo Mutation Studies TopNGS Mosaic SNV Studies TopNGS Other Studies Top Low Scale Gene Studies TopContact Us if you are an author of a study regarding this gene and do not find your study in this table or find errors in the representation of your study details.