Evidence Details for LZTS1
Basic Information Top
| Gene Symbol: | LZTS1 ( F37,FEZ1 ) |
|---|---|
| Gene Full Name: | leucine zipper, putative tumor suppressor 1 |
| Band: | 8p21.3 |
| Quick Links | Entrez ID:11178; OMIM: 606551; Uniprot ID:LZTS1_HUMAN; ENSEMBL ID: ENSG00000061337; HGNC ID: 13861 |
| Relate to Another Database: | SFARIGene; denovo-db |
Sequences Top>LZTS1|11178|nucleotide
ATGGGCAGCGTCAGTAGCCTCATCTCCGGCCACAGCTTCCACAGCAAGCACTGCCGGGCTTCGCAGTACAAGCTGCGCAAGTCCTCCCACCTCAAGAAGCTCAAC
CGGTATTCCGACGGGCTGCTGAGGTTTGGCTTCTCCCAGGACTCCGGTCACGGCAAGTCCAGCTCCAAAATGGGCAAGAGCGAAGACTTCTTCTACATCAAGGTC
AGCCAGAAAGCCCGGGGCTCCCATCACCCAGATTACACGGCACTGTCCAGCGGGGATTTAGGGGGCCAGGCTGGGGTGGACTTTGACCCGTCCACACCCCCCAAG
CTCATGCCCTTCTCCAATCAGCTAGAAATGGGCTCCGAGAAGGGTGCAGTGAGGCCCACAGCCTTCAAGCCTGTGCTGCCACGGTCAGGAGCCATCCTGCACTCC
TCCCCGGAGAGTGCCAGCCACCAGCTGCACCCCGCCCCTCCAGACAAGCCCAAGGAGCAGGAGCTGAAGCCTGGCCTGTGCTCTGGGGCGCTGTCAGACTCCGGC
CGGAACTCCATGTCCAGCCTGCCCACACACAGCACCAGCAGCAGCTACCAGCTGGACCCGCTGGTCACACCCGTGGGACCCACAAGCCGTTTTGGGGGCTCCGCC
CACAACATCACCCAGGGCATCGTCCTCCAGGACAGCAACATGATGAGCCTGAAGGCTCTGTCCTTCTCCGACGGAGGTAGCAAGCTGGGCCACTCGAACAAGGCA
GACAAGGGCCCCTCGTGTGTCCGCTCCCCCATCTCCACGGACGAGTGCAGCATCCAGGAGCTGGAGCAGAAGCTGTTGGAGAGGGAGGGCGCCCTCCAGAAGCTG
CAGCGCAGCTTTGAGGAGAAGGAGCTTGCCTCCAGCCTGGCCTACGAGGAGCGGCCGCGGCGCTGCAGGGACGAGCTGGAGGGCCCGGAGCCCAAAGGCGGCAAC
AAGCTCAAGCAGGCCTCGCAGAAGAGCCAGCGCGCGCAGCAGGTCCTGCACCTGCAGGTACTGCAGCTTCAGCAGGAGAAGCGGCAGCTCCGGCAGGAGCTCGAG
AGCCTCATGAAGGAGCAGGACCTGCTGGAGACCAAGCTCAGGTCCTACGAGAGGGAGAAGACCAGCTTCGGCCCCGCGCTGGAGGAGACCCAGTGGGAGGTGTGC
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ATGGGCAGCGTCAGTAGCCTCATCTCCGGCCACAGCTTCCACAGCAAGCACTGCCGGGCTTCGCAGTACAAGCTGCGCAAGTCCTCCCACCTCAAGAAGCTCAAC
CGGTATTCCGACGGGCTGCTGAGGTTTGGCTTCTCCCAGGACTCCGGTCACGGCAAGTCCAGCTCCAAAATGGGCAAGAGCGAAGACTTCTTCTACATCAAGGTC
AGCCAGAAAGCCCGGGGCTCCCATCACCCAGATTACACGGCACTGTCCAGCGGGGATTTAGGGGGCCAGGCTGGGGTGGACTTTGACCCGTCCACACCCCCCAAG
CTCATGCCCTTCTCCAATCAGCTAGAAATGGGCTCCGAGAAGGGTGCAGTGAGGCCCACAGCCTTCAAGCCTGTGCTGCCACGGTCAGGAGCCATCCTGCACTCC
TCCCCGGAGAGTGCCAGCCACCAGCTGCACCCCGCCCCTCCAGACAAGCCCAAGGAGCAGGAGCTGAAGCCTGGCCTGTGCTCTGGGGCGCTGTCAGACTCCGGC
CGGAACTCCATGTCCAGCCTGCCCACACACAGCACCAGCAGCAGCTACCAGCTGGACCCGCTGGTCACACCCGTGGGACCCACAAGCCGTTTTGGGGGCTCCGCC
CACAACATCACCCAGGGCATCGTCCTCCAGGACAGCAACATGATGAGCCTGAAGGCTCTGTCCTTCTCCGACGGAGGTAGCAAGCTGGGCCACTCGAACAAGGCA
GACAAGGGCCCCTCGTGTGTCCGCTCCCCCATCTCCACGGACGAGTGCAGCATCCAGGAGCTGGAGCAGAAGCTGTTGGAGAGGGAGGGCGCCCTCCAGAAGCTG
CAGCGCAGCTTTGAGGAGAAGGAGCTTGCCTCCAGCCTGGCCTACGAGGAGCGGCCGCGGCGCTGCAGGGACGAGCTGGAGGGCCCGGAGCCCAAAGGCGGCAAC
AAGCTCAAGCAGGCCTCGCAGAAGAGCCAGCGCGCGCAGCAGGTCCTGCACCTGCAGGTACTGCAGCTTCAGCAGGAGAAGCGGCAGCTCCGGCAGGAGCTCGAG
AGCCTCATGAAGGAGCAGGACCTGCTGGAGACCAAGCTCAGGTCCTACGAGAGGGAGAAGACCAGCTTCGGCCCCGCGCTGGAGGAGACCCAGTGGGAGGTGTGC
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>LZTS1|11178|protein
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPK
LMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSA
HNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN
KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGF
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MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPK
LMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSA
HNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGN
KLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLK
DTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGF
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Evidence summary TopClick the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
| Evidences | Syndromic Gene | GWAS | CNV | Linkage | Association | Expression | NGS de novo | NGS Mosaic | NGS Other | Low-Scale Gene Studies | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Score (No. of Studies) | No | 0 (1) | 1 (4) | 1 (1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 4 (6) |
Syndromic Autism Gene TopGenome-Wide Association Studies (By Ethnic Group) Top Family Based Association Studies: 1
| Reference | Stage | Platform | #Families | Affecteds | Result | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| #Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ (range) |
||||||
| CAUCASIAN | |||||||||||
| Hussman, 2011_1 | Discovery | Illumina Infinium Human 1 M beadship | 597 | - (-) |  |  | ASD | - - |
- - | ||
Case Control Based Association Studies: 0
| Reference | Stage | Platform | ASD Cases | Normal Controls | Result | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ | #Subjects (% Women) |
Age (range) |
|||||
| No Evidence. | ||||||||||||
CNV Studies Top| Reference | Source | Method | ADI-R | ADOS | Diagnosis | Family | Individual | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Simplex | Multiplex | Control | Affected | Control | Total | ||||||
| Papanikolaou, 2006 | - | FISH | | | autism | - | - | - | - | 1 | - | 1 |
| Gregory, 2009 | USA | aCGH | | | ASD | - | - | - | - | 119 | 54 | 173 |
| Ozgen, 2009 | - | aCGH, SNP microarray | | | ASD | 55 | - | - | - | - | - | - |
| Berkel, 2010 | Canada | SNP microarray | | | ASD | - | - | - | - | 396 | 5023 | 5419 |
Linkage Studies Top