AutismKB 2.0

Evidence Details for LEO1


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Basic Information Top
Gene Symbol:LEO1 ( RDL )
Gene Full Name: Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Band: 15q21.2
Quick LinksEntrez ID:123169; OMIM: 610507; Uniprot ID:LEO1_HUMAN; ENSEMBL ID: ENSG00000166477; HGNC ID: 30401
Relate to Another Database: SFARIGene; denovo-db
Sequences Top
>LEO1|123169|nucleotide
ATGGCGGATATGGAGGATCTCTTCGGGAGCGACGCCGACAGCGAAGCTGAGCGTAAAGATTCTGATTCTGGATCTGACTCAGATTCTGATCAAGAGAATGCTGCC
TCTGGCAGTAATGCCTCTGGAAGTGAAAGTGATCAGGATGAAAGAGGTGATTCAGGACAACCAAGTAATAAGGAACTGTTTGGAGATGACAGTGAGGACGAGGGA
GCTTCACATCATAGTGGTAGTGATAATCACTCTGAAAGATCAGACAATAGATCAGAAGCTTCTGAGCGTTCTGACCATGAGGACAATGACCCCTCAGATGTAGAT
CAGCACAGTGGATCAGAAGCCCCTAATGATGATGAAGACGAAGGTCATAGATCGGATGGAGGGAGCCATCATTCAGAAGCAGAAGGTTCTGAAAAAGCACATTCA
GATGATGAAAAATGGGGCAGAGAAGATAAAAGTGACCAGTCAGATGATGAAAAGATACAAAATTCTGATGATGAGGAGAGGGCACAAGGATCTGATGAAGATAAG
CTGCAGAATTCTGACGATGATGAGAAAATGCAGAACACAGATGATGAGGAGAGGCCTCAGCTTTCCGATGATGAGAGACAACAGCTATCTGAGGAGGAAAAGGCT
AATTCTGATGATGAACGGCCGGTAGCTTCTGATAATGATGATGAGAAACAGAATTCTGATGATGAAGAACAACCACAGCTGTCTGATGAAGAGAAAATGCAAAAT
TCTGATGATGAAAGGCCACAGGCCTCAGATGAAGAACACAGGCATTCAGATGATGAAGAGGAACAGGATCATAAATCAGAATCTGCAAGAGGCAGTGATAGTGAA
GATGAAGTTTTACGAATGAAACGCAAGAATGCGATTGCATCTGATTCAGAAGCGGATAGTGACACTGAGGTGCCAAAAGATAATAGTGGAACCATGGATTTATTT
GGAGGTGCAGATGATATCTCTTCAGGGAGTGATGGAGAAGACAAACCACCTACTCCAGGACAGCCTGTTGATGAAAATGGATTGCCTCAGGATCAACAGGAAGAG
GAGCCAATTCCTGAGACCAGAATAGAAGTAGAAATACCCAAAGTAAACACTGATTTAGGAAACGACTTATATTTTGTTAAACTGCCCAACTTTCTCAGTGTAGAG
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>LEO1|123169|protein
MADMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVD
QHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKA
NSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLF
GGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVENTI
RWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAG
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Evidence summary Top

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Evidences Syndromic Gene GWAS CNV Linkage Association Expression NGS de novo NGS Mosaic NGS Other Low-Scale Gene Studies Total
Score (No. of Studies) No 0 (0) 0 (1) 1 (1) 0 (0) 0 (0) 0 (1) 0 (0) 0 (0) 0 (0) 2 (3)
Syndromic Autism Gene Top
Genome-Wide Association Studies(By Ethnic Group) Top
CNV Studies Top
Reference Source Method ADI-R ADOS Diagnosis Family Individual
Total Simplex Multiplex Control Affected Control Total
Szatmari, 2007 Europe, North America SNP microarrayASD 1491 - - - - - 0
Linkage Studies Top