AutismKB 2.0

Evidence Details for LGI3


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Basic Information Top
Gene Symbol:LGI3 ( LGIL4 )
Gene Full Name: leucine-rich repeat LGI family, member 3
Band: 8p21.3
Quick LinksEntrez ID:203190; OMIM: 608302; Uniprot ID:LGI3_HUMAN; ENSEMBL ID: ENSG00000168481; HGNC ID: 18711
Relate to Another Database: SFARIGene; denovo-db
Sequences Top
>LGI3|203190|nucleotide
ATGGCGGGGCTGCGGGCCAGGGGGGGCCCGGGGCCGGGGCTGCTGGCGCTCTCCGCGCTCGGCTTCTGCCTCATGCTGCAAGTCAGCGCTAAGAGGCCCCCCAAG
ACGCCCCCCTGCCCGCCCAGCTGCTCTTGCACCAGGGACACCGCCTTCTGCGTGGACTCAAAGGCGGTGCCCAGGAACCTGCCCTCGGAGGTCATCTCCCTGACC
CTGGTGAATGCCGCCTTCTCAGAGATCCAGGATGGAGCGTTCTCCCACCTCCCGCTGCTGCAGTTCTTGTTACTCAACTCCAACAAGTTTACACTGATTGGAGAC
AACGCCTTCACAGGACTGTCGCACCTGCAGTATCTCTTCATTGAGAACAATGACATCTGGGCACTATCCAAGTTCACCTTCCGAGGACTCAAGTCCTTGACTCAC
CTCTCGCTGGCCAACAATAACCTGCAGACACTGCCCAGAGACATCTTCCGGCCCCTGGACATCCTGAATGACTTGGACCTGCGGGGCAACTCACTCAACTGTGAC
TGCAAGGTGAAGTGGTTGGTGGAGTGGCTGGCACACACCAACACCACGGTGGCACCCATCTACTGCGCCAGCCCGCCCCGCTTCCAGGAGCACAAGGTGCAGGAC
CTGCCGCTGCGGGAGTTCGATTGCATCACCACAGATTTTGTGTTGTACCAGACCCTGGCCTTCCCAGCAGTGTCGGCTGAGCCCTTCCTCTACTCCAGTGACCTC
TATTTGGCTCTGGCCCAGCCAGGAGTCAGTGCCTGCACCATCCTGAAGTGGGACTATGTTGAGCGGCAGCTTCGAGACTATGATAGAATCCCAGCCCCCTCTGCA
GTGCACTGCAAGCCGATGGTGGTGGACAGCCAGCTGTACGTGGTCGTGGCCCAGCTGTTTGGCGGCTCTTACATTTACCACTGGGATCCCAACACCACGCGCTTC
ACCAGGCTGCAAGACATTGACCCGCAGCGCGTGCGCAAGCCTAACGACCTAGAAGCCTTCCGCATCGACGGTGACTGGTACTTTGCCGTGGCTGACAGCTCCAAG
GCAGGCGCCACCAGCCTCTACCGCTGGCACCAGAATGGCTTCTACTCCCACCAGGCACTGCACCCCTGGCACCGTGACACCGACCTGGAGTTTGTGGACGGCGAG
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>LGI3|203190|protein
MAGLRARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGD
NAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQD
LPLREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYHWDPNTTRF
TRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYSHQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQV
PDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQ
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Evidence summary Top

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Evidences Syndromic Gene GWAS CNV Linkage Association Expression NGS de novo NGS Mosaic NGS Other Low-Scale Gene Studies Total
Score (No. of Studies) No 0 (0) 1 (3) 1 (1) 0 (0) 2 (2) 0 (0) 0 (0) 0 (0) 0 (0) 6 (6)
Syndromic Autism Gene Top
Genome-Wide Association Studies(By Ethnic Group) Top
CNV Studies Top
Reference Source Method ADI-R ADOS Diagnosis Family Individual
Total Simplex Multiplex Control Affected Control Total
Papanikolaou, 2006 - FISHautism - - - - 1 - 1
Ozgen, 2009 - aCGH, SNP microarrayASD 55 - - - - - -
Berkel, 2010 Canada SNP microarrayASD - - - - 396 5023 5419
Linkage Studies Top