AutismKB 2.0

Evidence Details for NLGN1


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Basic Information Top
Gene Symbol:NLGN1 ( KIAA1070,MGC45115,NL1 )
Gene Full Name: neuroligin 1
Band: 3q26.31
Quick LinksEntrez ID:22871; OMIM: 600568; Uniprot ID:NLGN1_HUMAN; ENSEMBL ID: ENSG00000169760; HGNC ID: 14291
Relate to Another Database: SFARIGene; denovo-db
Sequences Top
>NLGN1|22871|nucleotide
ATGGCACTGCCCAGATGCACGTGGCCAAATTATGTTTGGAGAGCAGTGATGGCATGCTTGGTACACCGGGGATTGGGTGCCCCATTGACTCTCTGTATGTTGGGA
TGTTTGCTTCAGGCTGGCCATGTGCTATCACAAAAATTGGATGATGTGGACCCACTGGTGGCTACCAACTTTGGAAAGATAAGAGGGATTAAGAAGGAACTCAAT
AATGAAATTTTGGGGCCTGTTATTCAATTTCTTGGGGTTCCATATGCAGCCCCACCAACAGGGGAACGTCGTTTTCAGCCTCCAGAACCACCATCTCCCTGGTCA
GATATCAGAAATGCCACTCAATTTGCTCCTGTGTGTCCCCAGAATATCATTGATGGCAGATTGCCAGAAGTCATGCTTCCTGTGTGGTTTACTAATAACTTGGAT
GTGGTTTCATCATATGTGCAAGACCAGAGCGAAGACTGCCTATATTTAAATATATATGTCCCGACTGAGGATGATATTCGGGACAGTGGGGGTCCCAAACCAGTG
ATGGTGTATATCCATGGTGGCTCATATATGGAAGGTACTGGAAATTTATATGATGGAAGTGTCTTGGCAAGTTATGGCAATGTGATCGTCATCACAGTCAACTAT
CGACTTGGAGTACTCGGTTTCTTGAGTACAGGCGATCAGGCTGCAAAGGGGAACTATGGACTCCTTGATCTCATACAAGCTTTAAGATGGACTAGTGAAAACATT
GGATTCTTTGGTGGTGACCCCTTAAGAATCACTGTTTTTGGATCTGGTGCTGGGGGTTCATGTGTCAACCTGCTGACTTTATCCCATTATTCTGAAGGTAACCGT
TGGAGCAATTCAACCAAAGGACTTTTTCAACGAGCAATAGCTCAAAGTGGAACAGCCCTTTCCAGCTGGGCTGTTAGTTTTCAACCTGCAAAATATGCTAGAATG
TTGGCCACAAAAGTTGGTTGCAATGTTTCAGATACAGTAGAGTTAGTGGAATGCCTACAGAAGAAGCCTTACAAAGAACTTGTTGACCAAGATATTCAACCAGCT
CGATACCACATAGCCTTTGGACCTGTGATTGATGGTGATGTAATACCAGACGACCCCCAGATATTGATGGAGCAAGGAGAGTTTCTCAACTATGATATAATGTTA
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>NLGN1|22871|protein
MALPRCTWPNYVWRAVMACLVHRGLGAPLTLCMLGCLLQAGHVLSQKLDDVDPLVATNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWS
DIRNATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNY
RLGVLGFLSTGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARM
LATKVGCNVSDTVELVECLQKKPYKELVDQDIQPARYHIAFGPVIDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVENIVDSDDGISASDFDFAVSNFVD
NLYGYPEGKDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFP
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Evidence summary Top

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Evidences Syndromic Gene GWAS CNV Linkage Association Expression NGS de novo NGS Mosaic NGS Other Low-Scale Gene Studies Total
Score (No. of Studies) No 0 (0) 0 (1) 1 (1) 1 (1) 0 (0) 0 (2) 0 (0) 0 (0) 0 (0) 4 (5)
Syndromic Autism Gene Top
Genome-Wide Association Studies(By Ethnic Group) Top
CNV Studies Top
Reference Source Method ADI-R ADOS Diagnosis Family Individual
Total Simplex Multiplex Control Affected Control Total
Glessner, 2009 - SNP microarrayASD - - - - 2195 2519 4714
Linkage Studies Top