AutismKB 2.0

Evidence Details for CAND2


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Basic Information Top
Gene Symbol:CAND2 ( KIAA0667,TIP120B,Tp120b )
Gene Full Name: cullin-associated and neddylation-dissociated 2 (putative)
Band: 3p25.2
Quick LinksEntrez ID:23066; OMIM: 610403; Uniprot ID:CAND2_HUMAN; ENSEMBL ID: ENSG00000144712; HGNC ID: 30689
Relate to Another Database: SFARIGene; denovo-db
Sequences Top
>CAND2|23066|nucleotide
ATGAGCACCGCCGCCTTCCACATCTCCAGCCTCCTGGAGAAGATGACGTCCAGCGACAAGGACTTCAGGTTCATGGCCACCAGCGACCTGATGTCGGAGTTGCAG
AAGGACTCCATCCAGCTGGACGAGGACAGCGAGCGCAAGGTGGTGAAGATGCTGCTCCGGCTCCTGGAGGACAAGAACGGTGAGGTGCAGAACCTGGCTGTCAAG
TGCCTGGGTCCTCTGGTGGTCAAAGTGAAGGAGTACCAGGTGGAGACCATTGTGGACACCCTGTGCACCAACATGCGGTCAGACAAGGAGCAGCTGCGAGACATT
GCCGGCATTGGCCTCAAGACCGTCCTCTCGGAGCTCCCTCCTGCAGCCACAGGCTCCGGGCTGGCCACCAACGTGTGCCGGAAGATCACAGGCCAGCTCACCAGT
GCCATTGCCCAGCAGGAGGATGTGGCTGTGCAGCTGGAAGCCCTGGACATCCTCTCTGACATGCTGAGCAGGCTGGGTGTCCCGCTGGGCGCCTTCCACGCCAGC
CTCCTGCACTGTCTGCTGCCACAGCTGAGCAGCCCGCGCCTGGCGGTGCGCAAGCGGGCGGTCGGAGCGCTTGGCCACCTGGCGGCCGCCTGCAGCACCGACCTC
TTCGTCGAGCTCGCTGACCACCTACTGGACCGGCTGCCCGGCCCGCGGGTGCCCACCAGCCCGACTGCCATCCGCACCCTGATCCAATGTTTGGGCAGCGTCGGC
CGCCAGGCCGGCCACCGCCTCGGGGCTCACCTGGACCGCCTGGTGCCCCTGGTGGAGGATTTCTGCAACCTGGATGATGATGAGCTCCGGGAGTCCTGCCTCCAG
GCTTTTGAGGCCTTCTTGAGGAAGTGCCCCAAGGAAATGGGTCCTCACGTGCCCAACGTGACCAGCCTCTGCCTCCAATACATAAAACACGACCCCAACTACAAC
TACGACAGTGATGAGGATGAGGAGCAGATGGAGACAGAGGATAGTGAATTCAGTGAGCAAGAGAGTGAAGACGAGTACAGCGATGACGATGACATGAGCTGGAAG
GTGCGCCGGGCAGCTGCCAAGTGCATCGCAGCCTTGATCAGCTCGCGGCCTGACCTGCTGCCCGATTTCCACTGCACCCTGGCACCTGTGCTCATCCGCCGCTTC
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>CAND2|23066|protein
MSTAAFHISSLLEKMTSSDKDFRFMATSDLMSELQKDSIQLDEDSERKVVKMLLRLLEDKNGEVQNLAVKCLGPLVVKVKEYQVETIVDTLCTNMRSDKEQLRDI
AGIGLKTVLSELPPAATGSGLATNVCRKITGQLTSAIAQQEDVAVQLEALDILSDMLSRLGVPLGAFHASLLHCLLPQLSSPRLAVRKRAVGALGHLAAACSTDL
FVELADHLLDRLPGPRVPTSPTAIRTLIQCLGSVGRQAGHRLGAHLDRLVPLVEDFCNLDDDELRESCLQAFEAFLRKCPKEMGPHVPNVTSLCLQYIKHDPNYN
YDSDEDEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCIAALISSRPDLLPDFHCTLAPVLIRRFKEREENVKADVFTAYIVLLRQTQPPKGWLEAMEEP
TQTGSNLHMLRGQVPLVVKALQRQLKDRSVRARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLADRSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPILLPP
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Evidence summary Top

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Evidences Syndromic Gene GWAS CNV Linkage Association Expression NGS de novo NGS Mosaic NGS Other Low-Scale Gene Studies Total
Score (No. of Studies) No 0 (0) 1 (3) 0 (0) 0 (0) 0 (0) 0 (1) 0 (0) 0 (0) 0 (0) 2 (4)
Syndromic Autism Gene Top
Genome-Wide Association Studies(By Ethnic Group) Top
CNV Studies Top
Reference Source Method ADI-R ADOS Diagnosis Family Individual
Total Simplex Multiplex Control Affected Control Total
Bucan, 2009 USA SNP microarrayautism, ASD 912 - 912 - - 1488 1488
Pinto, 2010 - SNP microarray, qPCRASD - - - - 996 1287 2283
Gai, 2011 AGRE SNP microarray--autism - - - - 1224 3801 5025
Linkage Studies Top