Evidence Details for ZFHX3
Basic Information Top
| Gene Symbol: | ZFHX3 ( ATBF1,ATBT,ZNF927 ) |
|---|---|
| Gene Full Name: | zinc finger homeobox 3 |
| Band: | 16q22.2-q22.3 |
| Quick Links | Entrez ID:463; OMIM: 104155; Uniprot ID:ZFHX3_HUMAN; ENSEMBL ID: ENSG00000140836; HGNC ID: 777 |
| Relate to Another Database: | SFARIGene; denovo-db |
Sequences Top>ZFHX3|463|nucleotide
ATGCGGCTCGGGGGCGGGCAGCTGGTGTCAGAGGAGCTGATGAACCTGGGCGAGAGCTTCATCCAGACCAACGACCCGTCGCTGAAGCTCTTCCAGTGCGCCGTC
TGCAACAAGTTCACGACGGACAACCTGGACATGCTGGGCCTGCACATGAACGTGGAGCGCAGCCTGTCGGAGGACGAGTGGAAGGCGGTGATGGGGGACTCATAC
CAGTGCAAGCTCTGCCGCTACAACACCCAGCTCAAGGCCAACTTCCAGCTGCACTGCAAGACAGACAAGCACGTGCAGAAGTACCAGCTGGTGGCCCACATCAAG
GAGGGCGGCAAGGCCAACGAGTGGAGGCTCAAGTGTGTGGCCATCGGCAACCCCGTGCACCTCAAGTGCAACGCCTGTGACTACTACACCAACAGCCTGGAGAAG
CTGCGGCTGCACACGGTCAACTCCAGGCACGAGGCCAGCCTGAAGTTGTACAAGCACCTGCAGCAGCATGAGAGTGGTGTAGAAGGTGAGAGCTGCTACTACCAC
TGCGTTCTGTGCAACTACTCCACCAAGGCCAAGCTCAACCTCATCCAGCATGTGCGCTCCATGAAGCACCAGCGAAGCGAGAGCCTGCGAAAGCTGCAGCGGCTG
CAGAAGGGCCTTCCAGAGGAGGACGAGGACCTGGGGCAGATCTTCACCATCCGCAGGTGCCCCTCCACGGACCCAGAAGAAGCCATTGAAGATGTTGAAGGACCC
AGTGAAACAGCTGCTGATCCAGAGGAGCTTGCTAAGGACCAAGAGGGCGGAGCATCGTCCAGCCAAGCAGAGAAGGAGCTGACAGATTCTCCTGCAACCTCCAAA
CGCATCTCCTTCCCAGGTAGCTCAGAGTCTCCCCTCTCTTCGAAGCGACCAAAAACAGCTGAGGAGATCAAACCGGAGCAGATGTACCAGTGTCCCTACTGCAAG
TACAGTAATGCCGATGTCAACCGGCTCCGGGTGCATGCCATGACGCAGCACTCGGTGCAACCCATGCTTCGCTGCCCCCTGTGCCAGGACATGCTCAACAACAAG
ATCCACCTCCAGCTGCACCTCACCCACCTCCACAGCGTGGCACCTGACTGCGTGGAGAAGCTCATTATGACGGTGACCACCCCTGAGATGGTGATGCCAAGCAGC
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ATGCGGCTCGGGGGCGGGCAGCTGGTGTCAGAGGAGCTGATGAACCTGGGCGAGAGCTTCATCCAGACCAACGACCCGTCGCTGAAGCTCTTCCAGTGCGCCGTC
TGCAACAAGTTCACGACGGACAACCTGGACATGCTGGGCCTGCACATGAACGTGGAGCGCAGCCTGTCGGAGGACGAGTGGAAGGCGGTGATGGGGGACTCATAC
CAGTGCAAGCTCTGCCGCTACAACACCCAGCTCAAGGCCAACTTCCAGCTGCACTGCAAGACAGACAAGCACGTGCAGAAGTACCAGCTGGTGGCCCACATCAAG
GAGGGCGGCAAGGCCAACGAGTGGAGGCTCAAGTGTGTGGCCATCGGCAACCCCGTGCACCTCAAGTGCAACGCCTGTGACTACTACACCAACAGCCTGGAGAAG
CTGCGGCTGCACACGGTCAACTCCAGGCACGAGGCCAGCCTGAAGTTGTACAAGCACCTGCAGCAGCATGAGAGTGGTGTAGAAGGTGAGAGCTGCTACTACCAC
TGCGTTCTGTGCAACTACTCCACCAAGGCCAAGCTCAACCTCATCCAGCATGTGCGCTCCATGAAGCACCAGCGAAGCGAGAGCCTGCGAAAGCTGCAGCGGCTG
CAGAAGGGCCTTCCAGAGGAGGACGAGGACCTGGGGCAGATCTTCACCATCCGCAGGTGCCCCTCCACGGACCCAGAAGAAGCCATTGAAGATGTTGAAGGACCC
AGTGAAACAGCTGCTGATCCAGAGGAGCTTGCTAAGGACCAAGAGGGCGGAGCATCGTCCAGCCAAGCAGAGAAGGAGCTGACAGATTCTCCTGCAACCTCCAAA
CGCATCTCCTTCCCAGGTAGCTCAGAGTCTCCCCTCTCTTCGAAGCGACCAAAAACAGCTGAGGAGATCAAACCGGAGCAGATGTACCAGTGTCCCTACTGCAAG
TACAGTAATGCCGATGTCAACCGGCTCCGGGTGCATGCCATGACGCAGCACTCGGTGCAACCCATGCTTCGCTGCCCCCTGTGCCAGGACATGCTCAACAACAAG
ATCCACCTCCAGCTGCACCTCACCCACCTCCACAGCGTGGCACCTGACTGCGTGGAGAAGCTCATTATGACGGTGACCACCCCTGAGATGGTGATGCCAAGCAGC
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>ZFHX3|463|protein
MRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIK
EGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRL
QKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCK
YSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILP
SASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFR
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MRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIK
EGGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRL
QKGLPEEDEDLGQIFTIRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTAEEIKPEQMYQCPYCK
YSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILP
SASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFR
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Evidence summary TopClick the link of the category-specific score to view different category of evidences. The categories without any evidences are hidden by default.
| Evidences | Syndromic Gene | GWAS | CNV | Linkage | Association | Expression | NGS de novo | NGS Mosaic | NGS Other | Low-Scale Gene Studies | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Score (No. of Studies) | No | 0 (1) | 1 (2) | 0 (0) | 0 (0) | 0 (0) | 0 (2) | 0 (0) | 0 (1) | 0 (0) | 2 (6) |
Syndromic Autism Gene TopGenome-Wide Association Studies (By Ethnic Group) Top Family Based Association Studies: 1
| Reference | Stage | Platform | #Families | Affecteds | Result | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| #Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ (range) |
||||||
| CAUCASIAN | |||||||||||
| Hussman, 2011_1 | Discovery | Illumina Infinium Human 1 M beadship | 597 | - (-) |  |  | ASD | - - |
- - | ||
Case Control Based Association Studies: 0
| Reference | Stage | Platform | ASD Cases | Normal Controls | Result | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #Subjects (% Women) |
ADI-R | ADOS | Diagnosis | Age (range) |
IQ | #Subjects (% Women) |
Age (range) |
|||||
| No Evidence. | ||||||||||||
CNV Studies Top| Reference | Source | Method | ADI-R | ADOS | Diagnosis | Family | Individual | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Simplex | Multiplex | Control | Affected | Control | Total | ||||||
| Wassink, 2001 | USA | Chromosomal analysis of G-band | | | autism | - | - | - | - | 278 | - | 278 |
| Sanders, 2011 | Simons Simplex Collection | SNP microarray | - | - | ASD | 1127 | 1127 | - | - | - | - | - |
Linkage Studies TopLow Scale Association Studies (by Ethnic Group) TopLarge Scale Expression Studies TopNGS de novo Mutation Studies Top| Reference | Case Number | Family Number | de novo Number | Title |
|---|---|---|---|---|
| De Rubeis S, 2014 | 2270 | - | 1702 | Synaptic, transcriptional and chromatin genes disrupted in autism |
| Hashimoto R, 2016 | 30 | - | 38 | Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. |
NGS Mosaic SNV Studies TopNGS Other Studies Top| Reference | Source | Platform | ADI-R | ADOS | Diagnosis | Family | Affected | Validation Method | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Total | Simplex | Multiplex | ||||||||
| Toma C, 2014 | - | Illumina HiSeq 2000 | - | - | ASD | 10 | - | - | 21 | - |
Low Scale Gene Studies TopContact Us if you are an author of a study regarding this gene and do not find your study in this table or find errors in the representation of your study details.