AutismKB 2.0

Evidence Details for DUOX2


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Basic Information Top
Gene Symbol:DUOX2 ( LNOX2,NOXEF2,P138-TOX,TDH6,THOX2 )
Gene Full Name: dual oxidase 2
Band: 15q21.1
Quick LinksEntrez ID:50506; OMIM: 606759; Uniprot ID:DUOX2_HUMAN; ENSEMBL ID: ENSG00000140279; HGNC ID: 13273
Relate to Another Database: SFARIGene; denovo-db
Sequences Top
>DUOX2|50506|nucleotide
ATGCTCCGTGCAAGACCAGAGGCACTGATGCTCCTGGGAGCTCTTCTGACTGGATCCCTGGGTCCATCGGGCAATCAGGACGCACTCTCACTGCCCTGGGAAGTG
CAGCGCTATGACGGCTGGTTTAACAACCTGAGGCACCACGAGCGTGGTGCTGTTGGCTGCCGGTTGCAGCGCCGCGTACCAGCCAATTACGCCGACGGTGTGTAT
CAGGCTCTGGAGGAGCCGCAGCTGCCCAACCCGCGCCGGCTCAGCAACGCAGCCACGCGGGGCATAGCCGGCCTGCCGTCGCTCCACAACCGCACCGTACTGGGG
GTCTTCTTTGGCTACCATGTTCTTTCCGACGTGGTGAGCGTGGAAACGCCCGGTTGCCCCGCCGAGTTCCTCAACATCCGCATCCCACCTGGAGACCCCGTGTTC
GACCCCGACCAGCGCGGGGACGTGGTGCTGCCCTTCCAGAGGAGCCGCTGGGACCCCGAGACCGGACGGAGTCCCAGCAACCCCCGGGACCTGGCCAACCAGGTG
ACGGGCTGGCTGGACGGCAGCGCCATCTATGGCTCCTCGCACTCCTGGAGCGACGCGCTGCGGAGCTTCTCGGGGGGACAGCTGGCGTCGGGGCCCGACCCCGCT
TTCCCCCGAGACTCGCAGAACCCCCTGCTCATGTGGGCGGCGCCCGACCCCGCCACCGGGCAGAACGGGCCCCGGGGGCTGTACGCCTTCGGGGCAGAGAGAGGG
AACCGGGAACCCTTCCTGCAGGCGCTGGGCCTGCTCTGGTTCCGCTACCACAACCTGTGGGCGCAGAGGCTGGCCCGCCAGCACCCAGACTGGGAGGACGAGGAG
CTGTTCCAGCACGCACGCAAGAGGGTCATCGCCACCTACCAGAACATCGCTGTGTATGAGTGGCTGCCCAGCTTCCTGCAGAAAACACTCCCGGAGTATACAGGA
TACCGTCCTTTCCTAGACCCCAGCATCTCCCCGGAATTTGTGGTGGCCTCTGAGCAGTTCTTCTCTACCATGGTGCCCCCTGGTGTCTACATGAGAAATGCCAGC
TGTCATTTCCGGAAGGTCCTGAACAAGGGTTTTCAAAGCTCCCAAGCTCTCAGGGTCTGCAACAACTACTGGATTCGGGAGAACCCCAATCTGAACAGTACCCAG
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>DUOX2|50506|protein
MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLG
VFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPA
FPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTG
YRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKF
SRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNG
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Evidence summary Top

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Evidences Syndromic Gene GWAS CNV Linkage Association Expression NGS de novo NGS Mosaic NGS Other Low-Scale Gene Studies Total
Score (No. of Studies) No 0 (0) 1 (1) 1 (1) 0 (0) 0 (0) 0 (1) 0 (0) 0 (0) 0 (0) 4 (3)
Syndromic Autism Gene Top
Genome-Wide Association Studies(By Ethnic Group) Top
CNV Studies Top
Reference Source Method ADI-R ADOS Diagnosis Family Individual
Total Simplex Multiplex Control Affected Control Total
Zwaag, 2009 - SNP microarrayautism - - - - 105 267 372
Linkage Studies Top