AutismKB 2.0

Evidence Details for INTS10


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Basic Information Top
Gene Symbol:INTS10 ( C8orf35,FLJ10569,INT10 )
Gene Full Name: integrator complex subunit 10
Band: 8p21.3
Quick LinksEntrez ID:55174; OMIM: 611353; Uniprot ID:INT10_HUMAN; ENSEMBL ID: ENSG00000104613; HGNC ID: 25548
Relate to Another Database: SFARIGene; denovo-db
Sequences Top
>INTS10|55174|nucleotide
ATGTCTGCCCAGGGGGACTGCGAGTTCCTGGTGCAGCGAGCCCGGGAGTTGGTGCCGCAAGACCTGTGGGCAGCCAAGGCGTGGCTGATCACGGCCCGCAGCCTC
TACCCGGCAGACTTTAACATCCAGTATGAGATGTACACCATCGAGCGGAATGCAGAGCGGACCGCCACCGCCGGGAGGCTGCTGTACGACATGTTTGTGAATTTC
CCAGACCAGCCGGTGGTGTGGAGAGAAATCAGCATTATTACATCAGCATTAAGGAACGATTCACAGGACAAACAAACCCAATTTTTAAGAAGTTTATTTGAAACT
CTTCCTGGTCGGGTCCAGTGTGAAATGTTACTAAAGGTCACGGAACAATGCTTCAACACGTTAGAACGATCAGAAATGTTGCTTCTACTTTTGAGGCGCTTCCCT
GAAACGGTGGTGCAGCATGGGGTTGGCCTTGGGGAGGCACTATTAGAGGCTGAAACTATTGAAGAACAAGAATCTCCAGTGAACTGCTTTAGAAAATTATTTGTT
TGTGATGTCCTTCCTCTAATAATTAACAACCATGATGTTCGATTACCTGCCAATTTATTGTATAAGTACTTGAACAAAGCAGCTGAATTTTATATCAATTATGTC
ACTAGGTCTACTCAAATAGAAAATCAGCATCAAGGCGCCCAGGATACATCTGATTTAATGTCACCTAGCAAACGTAGCTCTCAGAAGTACATAATAGAAGGGCTG
ACGGAAAAATCATCCCAGATCGTGGACCCTTGGGAGAGGTTGTTTAAGATTTTGAATGTTGTTGGAATGAGATGTGAATGGCAGATGGATAAAGGAAGACGAAGC
TATGGAGATATTTTGCATAGAATGAAGGATCTCTGCAGATACATGAACAACTTTGATAGTGAAGCACATGCAAAATATAAAAACCAAGTGGTGTATTCCACCATG
CTGGTCTTCTTTAAGAATGCATTCCAGTATGTCAACAGCATACAGCCATCTCTCTTCCAAGGTCCTAATGCCCCGAGCCAAGTTCCACTGGTTCTTCTTGAAGAT
GTATCGAATGTGTATGGTGATGTAGAAATTGATCGTAATAAACACATCCATAAAAAGAGGAAACTAGCTGAAGGAAGAGAAAAAACCATGAGTTCAGACGATGAA
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>INTS10|55174|protein
MSAQGDCEFLVQRARELVPQDLWAAKAWLITARSLYPADFNIQYEMYTIERNAERTATAGRLLYDMFVNFPDQPVVWREISIITSALRNDSQDKQTQFLRSLFET
LPGRVQCEMLLKVTEQCFNTLERSEMLLLLLRRFPETVVQHGVGLGEALLEAETIEEQESPVNCFRKLFVCDVLPLIINNHDVRLPANLLYKYLNKAAEFYINYV
TRSTQIENQHQGAQDTSDLMSPSKRSSQKYIIEGLTEKSSQIVDPWERLFKILNVVGMRCEWQMDKGRRSYGDILHRMKDLCRYMNNFDSEAHAKYKNQVVYSTM
LVFFKNAFQYVNSIQPSLFQGPNAPSQVPLVLLEDVSNVYGDVEIDRNKHIHKKRKLAEGREKTMSSDDEDCSAKGRNRHIVVNKAELANSTEVLESFKLARESW
ELLYSLEFLDKEFTRICLAWKTDTWLWLRIFLTDMIIYQGQYKKAIASLHHLAALQGSISQPQITGQGTLEHQRALIQLATCHFALGEYRMTCEKVLDLMCYMVL
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Evidence summary Top

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Evidences Syndromic Gene GWAS CNV Linkage Association Expression NGS de novo NGS Mosaic NGS Other Low-Scale Gene Studies Total
Score (No. of Studies) No 0 (0) 1 (3) 1 (1) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 4 (4)
Syndromic Autism Gene Top
Genome-Wide Association Studies(By Ethnic Group) Top
CNV Studies Top
Reference Source Method ADI-R ADOS Diagnosis Family Individual
Total Simplex Multiplex Control Affected Control Total
Papanikolaou, 2006 - FISHautism - - - - 1 - 1
Ozgen, 2009 - aCGH, SNP microarrayASD 55 - - - - - -
Berkel, 2010 Canada SNP microarrayASD - - - - 396 5023 5419
Linkage Studies Top