AutismKB 2.0

Evidence Details for TIAM1


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Basic Information Top
Gene Symbol:TIAM1 ( FLJ36302 )
Gene Full Name: T-cell lymphoma invasion and metastasis 1
Band: 21q22.11
Quick LinksEntrez ID:7074; OMIM: 600687; Uniprot ID:TIAM1_HUMAN; ENSEMBL ID: ENSG00000156299; HGNC ID: 11805
Relate to Another Database: SFARIGene; denovo-db
Sequences Top
>TIAM1|7074|nucleotide
ATGGGAAACGCAGAAAGTCAACATGTAGAGCACGAGTTTTATGGAGAAAAGCATGCCAGCCTGGGGCGCAAGCACACTTCCCGCTCCCTGCGCCTCTCGCACAAG
ACGCGGAGGACCAGGCACGCTTCCTCGGGGAAGGTGATCCACAGGAACTCCGAAGTGAGCACCCGATCCAGCAGCACCCCCAGCATCCCCCAGTCCCTGGCTGAA
AATGGCCTGGAGCCCTTCTCCCAAGATGGTACCCTAGAAGACTTCGGGAGCCCCATCTGGGTGGACCGAGTGGACATGGGCTTGAGACCTGTGTCTTACACTGAC
TCTTCTGTCACTCCCAGCGTAGACAGCAGCATCGTCCTCACAGCAGCCTCTGTGCAGAGCATGCCAGACACTGAGGAGAGCAGGCTTTACGGGGATGACGCTACA
TATTTGGCTGAGGGAGGCAGGAGGCAGCATTCCTATACATCCAATGGGCCCACTTTCATGGAGACGGCGAGCTTTAAGAAGAAACGCTCCAAATCTGCAGACATC
TGGCGGGAGGACAGCCTGGAATTCTCACTCTCTGATCTGAGCCAAGAACATTTAACAAGCAACGAAGAAATCTTGGGTTCCGCCGAAGAGAAGGACTGCGAGGAG
GCTCGGGGGATGGAAACGCGGGCGAGTCCGCGGCAGCTCAGCACCTGTCAGAGAGCCAATTCCTTGGGTGACTTGTATGCTCAGAAAAACTCTGGAGTGACAGCA
AACGGGGGGCCGGGGAGCAAATTTGCAGGCTACTGTCGGAATTTGGTGTCTGATATTCCCAATCTTGCAAACCATAAGATGCCACCAGCTGCTGCTGAAGAGACT
CCTCCGTACAGTAATTATAACACACTTCCCTGTAGGAAATCTCACTGTCTCTCTGAAGGTGCCACCAACCCACAAATTAGCCATAGCAACAGCATGCAAGGCAGA
AGAGCTAAAACAACTCAGGATGTTAATGCAGGCGAGGGCAGTGAGTTTGCAGACAGTGGGATTGAAGGGGCCACTACCGACACGGACCTCCTGTCCAGGCGATCT
AATGCCACCAACTCCAGCTACTCACCCACCACAGGCCGGGCCTTTGTGGGCAGCGACAGCGGCAGCAGCTCCACCGGGGATGCGGCTCGTCAGGGGGTGTACGAG
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>TIAM1|7074|protein
MGNAESQHVEHEFYGEKHASLGRKHTSRSLRLSHKTRRTRHASSGKVIHRNSEVSTRSSSTPSIPQSLAENGLEPFSQDGTLEDFGSPIWVDRVDMGLRPVSYTD
SSVTPSVDSSIVLTAASVQSMPDTEESRLYGDDATYLAEGGRRQHSYTSNGPTFMETASFKKKRSKSADIWREDSLEFSLSDLSQEHLTSNEEILGSAEEKDCEE
ARGMETRASPRQLSTCQRANSLGDLYAQKNSGVTANGGPGSKFAGYCRNLVSDIPNLANHKMPPAAAEETPPYSNYNTLPCRKSHCLSEGATNPQISHSNSMQGR
RAKTTQDVNAGEGSEFADSGIEGATTDTDLLSRRSNATNSSYSPTTGRAFVGSDSGSSSTGDAARQGVYENFRRELEMSTTNSESLEEAGSAHSDEQSSGTLSSP
GQSDILLTAAQGTVRKAGALAVKNFLVHKKNKKVESATRRKWKHYWVSLKGCTLFFYESDGRSGIDHNSIPKHAVWVENSIVQAVPEHPKKDFVFCLSNSLGDAF
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Evidence summary Top

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Evidences Syndromic Gene GWAS CNV Linkage Association Expression NGS de novo NGS Mosaic NGS Other Low-Scale Gene Studies Total
Score (No. of Studies) No 0 (0) 1 (1) 0 (0) 0 (0) 1 (1) 0 (1) 0 (0) 0 (0) 0 (0) 3 (3)
Syndromic Autism Gene Top
Genome-Wide Association Studies(By Ethnic Group) Top
CNV Studies Top
Reference Source Method ADI-R ADOS Diagnosis Family Individual
Total Simplex Multiplex Control Affected Control Total
Egger G, 2014 Austria Microarray--ASD 73 - - - 245 2357 -
Linkage Studies Top
Low Scale Association Studies (by Ethnic Group) Top
Large Scale Expression Studies Top
Microarray Studies: 1
Reference Source Tissue #Subjects
(% Women)
ADI-R ADOS Endo- pheno Diagnosis Normal Controls
(% Women)
Fold Change Up/ Down P/Q value
Voineagu, 2011_1 Unknown 16 frontal cortex(BA9) and 13 temporal cortex(BA41 16
(25.00%)
-autism 16
(6.25%)
1.10141 Up 20.8011
  • Platform: Illumina Ref8 v3 microarrays
  • ProbeSet: ILMN_1655577
  • RefSeq_ID/ EST: -
  • GEO_ID: GSE28521
  • Statistic Method: SAM package and unless otherwise specified the significance threshold was FDR,0.05 and fold changes.1.3.
Proteomics Studies:0
Reference Source Tissue Platform #Subjects
(% Women)
ADI-R ADOS Diagnosis Normal Controls(% Women)
No Evidence.
NGS de novo Mutation Studies Top
Reference Case Number Family Number de novo Number Title
Iossifov I, 2014 2508 - 1194 The contribution of de novo coding mutations to autism spectrum disorder.
NGS Mosaic SNV Studies Top
NGS Other Studies Top
Low Scale Gene Studies Top

Contact Us if you are an author of a study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018